nitrofurazone is one of the antibacterial nitrofuran agents used topically for skin infections. the drug is effective on the majority of infectious microorganisms. because of the importance of this drug in clinic, in this study various methods of synthesis of nitrofurazone were examined and the most appropriate method, applicable to pharmaceutical industry was chosen and optimized from the poin...

The aim of the present study was to develop drug immunoconjugates (DIC) of antibiotics like Ampicillin trihydrate, Amoxycillin trihydrate, Streptomycin sulphate, Rifampicin and doxorubicin with Anti-D serum using different coupling methods. Protein content in AntiD serum was estimated by Lowry’s method. The conjugates were purified from unbound drug by dialysis. The drugs to antibody ratios wer...

Background: Asparagus racemosus (Shatavari) is widely used in Kerala, for the treatment of urinary tract infection (UTI) both by the rural folks and by traditional doctors without any scientific evidence. In this context, we decided to evaluate the antibacterial property of A. racemosus against common organisms causing UTI. Aims and Objective: To evaluate and compare the antibacterial activity ...

Background: The presence of antibacterial drug residues in food caused many concerns for consumers. This study was designed to determine of antibacterial drug residues in commercial eggs distributed in Urmia, Iran. Methods: Disc diffusion microbial inhibition test was performed using three media seeded with Bacillus subtilis at different pH values (6, 7.2 or 8) and a fourth medium seeded with M...

To understand the application of antibacterial agents in aseptic operations and to provide evidence for their rational use and management, the antibiotic use statuses of six types of aseptic operations (306 cases from 4 tertiary hospitals) were retrospectively analyzed. Of 312 patients, 306 (65.08%) were treated with antibacterial agents in the perioperative period. Four categories of antibioti...

The increasing presence of drug-resistant bacterial infections among hospitalAbstract ised patients has resulted in greater numbers of patients receiving inappropriate antimicrobial treatment. This has led to the development of a novel paradigm guiding the administration of empirical antimicrobial therapy for patients with serious infections in the hospital setting. Antibacterial de-escalation ...

Antibacterial Effect of Matricaria chamomilla Alcoholic Extract against Drug-Resistant Isolates Staphylococcus aureus and Pseudomonas aeruginosa

Four naphtho-γ-pyrones (fonsecinones A and C and aurasperones A and E) were identified as potential antibacterial agents against Escherichia coli, extended-spectrum β-lactamase (ESBL)-producing E. coli, Pseudomonas aeruginosa, Enterococcus faecalis, and methicillin-resistant Staphylococcus aureus (MRSA) in an in vitro antibacterial screen of 218 fungal metabolites. Fonsecinone A (2) exhibited t...