Citation: Zhang X, Zhao M, Yan J, Yang L, Yang Y, Guan W, Walcott R and Zhao T (2018) Involvement of hrpX and hrpG in the Virulence of Acidovorax citrulli Strain Aac5, Causal Agent of Bacterial Fruit Blotch in Cucurbits. Front. Microbiol. 9:507. doi: 10.3389/fmicb.2018.00507 Involvement of hrpX and hrpG in the Virulence of Acidovorax citrulli Strain Aac5, Causal Agent of Bacterial Fruit Blotch ...

fusarium oxysporum f. sp. lycopersici (fol) is the causal agent of vascular wilt in tomato, an important plant disease in iran. four monogenic resistance genes in tomato are used for identification of races of fol and their corresponding avirulence genes avr1, avr2 and avr3 were identified in pathogen one of which, avr2, is f.sp. specific. hence they can serve as reliable markers for racial ide...

Sortase A (SrtA)-catalyzed anchorage of surface proteins in most Gram-positive bacteria is indispensable for their virulence, suggesting that this transpeptidase is a promising target for antivirulence therapy. Here, an oligopeptide, LPRDA, was identified as an effective inhibitor of SrtA via virtual screening based on the LPXTG substrate sequence, and it was found to inhibit SrtA activity in v...

Cholera, a waterborne acute diarrheal disease caused by Vibrio cholerae, remains prevalent in underdeveloped countries and is a serious health threat to those living in unsanitary conditions. The major virulence factor is cholera toxin (CT), which consists of two subunits: the A subunit (CTA) and the B subunit (CTB). CTB is a 55 kD homopentameric, non-toxic protein binding to the GM1 gangliosid...

Legionella pneumophila, the major causative agent of Legionnaires' disease, is found in freshwater environments in close association with free-living amoebae and multispecies biofilms, leading to persistence, spread, biocide resistance, and elevated virulence of the bacterium. Indeed, legionellosis outbreaks are mainly due to the ability of this bacterium to colonize and persist in water facili...

Implant-associated infections (IAIs) caused by S. aureus can result in serious challenges after orthopedic surgery. Due to biofilm formation and antibiotic resistance, this refractory infection is highly prevalent, finding drugs attenuate bacterial virulence becoming a rational alternative strategy. In aureus, the SaeRS two-component system (TCS) plays key role production of over 20 factors pat...

Candida albicans is an opportunistic fungal pathogen that highly resistant to contemporary antifungals, due their biofilm lifestyle. The ability of C. invade human tissues its filamentation. Therefore, inhibition biofilms and filamentation the yeast are high value targets develop next-generation antifungals. Curcumin (CU) a natural polyphenol with excellent pharmacological attributes, but limit...

Honey is an excellent source of polyphenolic compounds that are effective in attenuating quorum sensing (QS), a chemical process of cell-to-cell communication system used by the opportunistic pathogen Pseudomonas aeruginosa to regulate virulence and biofilm formation. However, lower water solubility and inadequate bioavailability remains major concerns of these therapeutic polyphenols. Its ther...

Host resistance to parasites can come in two main forms: hosts may either reduce the probability of parasite infection (anti-infection resistance) or reduce parasite growth after infection has occurred (anti-growth resistance). Both resistance mechanisms are often imperfect, meaning that they do not fully prevent or clear infections. Theoretical work has suggested that imperfect anti-growth res...

The rise of antibiotic resistance calls for alternative strategies to treat bacterial infections. One attractive strategy is to directly target bacterial virulence factors with anti-virulence drugs. The expression of virulence traits by pathogens is, however, not constitutive but rather induced by the level of stress encountered within the host. Here we use dual RNA sequencing (RNA-seq) to show...