The patient-derived tumor xenograft (PDTX) models can reproduce a similar natural genetic background and similar biological behaviors to tumor cells in patients, which is conducive to the assessment of personalized cancer treatment. In this study, to verify the targeting and effectiveness of the therapeutic strategy using a Survivin promoter-regulated oncolytic adenovirus expressing Hsp70, the ...

PURPOSE We previously showed that targeting Delta-like ligand 4 (DLL4) in colon and breast tumors inhibited tumor growth and reduced tumor initiating cell frequency. In this report, we have extended these studies to pancreatic cancer and probed the mechanism of action in tumor and stromal cells involved in antitumor efficacy. EXPERIMENTAL DESIGN Patient-derived pancreatic xenograft tumor mode...

Erianin, a phytoestrogen with therapeutic potential, is one of the major active components Dendrobll caulis. Erianin has variety pharmacological effects, such as anti-tumor, anti-inflammatory, anti-diabetic retinopathy, anti-psoriasis, and antibacterial effects. Especially, in regard to anti-tumor effect erianin, underlying molecular mechanism been partly clarified. In fact, numerous actions er...

Highly significant suppression of the growth of S1509a and Sa-I syngeneic sarcomas was observed in A/J mice following daily intravenous injections of 2 microliter of anti-I-Jk alloantiserum. This effect persisted as long as the anti-I-Jk serum was administered (day 15), In contrast, a control anti-I-Js serum had no discernible effect on the growth of the S1509a tumor. The inhibitory activity of...

Objective(s): Blocking of vascular endothelial growth factor (VEGF) plays a pivotal role in inhibition of metastasis and is a target for development of anti-angiogenic agents. In this study, a peptide-based vaccine was designed and its potential for induction of humoral immune responses, generation of neutralizing antibodies, inhibition of tumor growth and metastasis w...

background: trace elements play an important role in a number of biological processes. astaxanthin (asx), a carotoid pigment found in certain marine plant and animals, has shown anti cancer and anti free radical properties. this work intended to understand the effect of astaxanthin in breast cancer (invasive ductal carcinoma, idc) by using micro-pixe method. for this aim the concentration of tr...

licorice, the oldest chinese traditional medicine, is widely used in the treatment of human diseases. due to the deficiency of wild resource, selecting and breeding becomes a key issue to expanding the supply of licorice. spaceflight technology will become a new method for medicinal plants. the aim of this study was to investigate the effect of spaceflight on the components and anti-inflammator...

The cGAS/STING signaling pathway plays a pivotal role in regulating innate immunity. Emerging novel drugs aim to regulate the anti-tumor immune response by activating anti-diabetic drug metformin has been reported exhibit anti-cancer effect against various types of cancer. However, gastric cancer remains unknown. In our study, we first used bioinformatic analysis detect that is closely related ...