Gall-stone ileus associated with tuberculous strictures is an uncommon cause of bowel obstruction related to a cholecystoenteric fistula. The stone usually obstructs the narrowest part of the intestine. The patient whose intestine is strictured due to tuberculosis or other disease, the stone can impact that part of the strictured area. We report such a case of gall-stone ileus in a patient of 8...

Neutropenia is a rare complication of anti-tuberculous therapy and is usually due to a single agent, most frequently isoniazid. The current case describes a previously healthy immunocompetent patient with tuberculosis of the lymph nodes who developed neutropenia due to a number of first line antibiotics (rifampicin, isoniazid and ethambutol) and streptomycin when introduced in combination and i...

BACKGROUND Uveitis involving the posterior segment is a significant and potentially blinding condition. The diagnosis and treatment of patients with uveitis associated with tuberculosis remains controversial, and commonly, patients are systemically well. Use of the interferon-gamma release assays has added to the controversy, as the significance of a positive test may be uncertain. We aim to re...

Although both lung cancer and pulmonary tuberculosis (TB) commonly occur in clinical practice, little attention has been paid to their coexistence. A 62-year-old female was admitted with acute dyspnoea secondary to cardiac tamponade. During her admission, a mass lesion harbouring air bronchograms in the right upper lobe rapidly increased in size. Surgical lung, pericardial, and pleural specimen...

objective(s) aristolochia indica has been widely used in the traditional medicine for the treatment of a variety of diseases. in the present study different extracts of roots of a. indica were evaluated for their anti­inflammatory, antipruritic and mast cell stabilizing activity. materials and methods anti-inflammatory activity was performed by compound 48/80 induced rat paw edema model and ant...

Cerebrospinal fluid (CSF) and serum samples from eight patients with bacteriologically proven (6) or clinically suspected (2) tuberculous meningitis were tested for the presence of anti-mycobacterial IgG antibodies by an affinity-mediated immunoblot technique. This technique is based on agarose gel isoelectric focusing of paired CSF and serum samples diluted to the same IgG concentration, and t...

OBJECTIVE To compare the efficacy of British Thoracic Society and American Thoracic Society guidelines for reintroduction of anti-tuberculous therapy after drug-induced liver injury, and to assess the ease of administration of each guideline on a scale of 1-10. METHODS The randomised prospective interventional study was conducted at the Department of Medicine and Pulmonology, Dow University o...

BACKGROUND Although it has been recognized that Mycobacterium tuberculosis contains large amounts of Toll-like receptor 2 (TLR2) ligands, their direct effects on CD4(+) T cells and the clinical implications have not been determined. METHODS With the recent finding that activated CD4(+) T cells express TLR2 as a costimulatory receptor, we hypothesized that M. tuberculosis and its components ma...

Recovery of adrenocortical function following treatment of tuberculous Addison's disease Sir, Penrice and Nussey report two cases of Addison's disease in which adrenocortical function recovered following treatment of tuberculosis.' Adrenal glands may be enlarged or atrophic in patients with Addison's disease due to t iberculosis. Large glands in tuberculosis mean a recent and probably active in...

We studied the activity of adenosine deaminase in the peritoneal fluid of 66 patients who were divided into five groups according to causes of ascites as follows: tuberculous peritonitis (group I), septic peritonitis (group II), secondary to malignant tumours (group III), miscellaneous conditions (group IV), and control subjects of transudates (group V). In patients with tuberculous peritonitis...