The adverse reactions of anti-tuberculosis drugs mainly include drug-induced liver injury, gastrointestinal reactions, and skin rash. Currently, the first-line anti-tuberculosis strategy in China includes the application of isoniazide, rifampicin, pyrazinamide, and ethambutol. Despite the high effectiveness, the serious adverse reactions caused by this strategy may cause a lot of patients disco...

Efficient tuberculosis treatment requires the use of good quality medicines. The present study developed a method of dosage by High Performance Liquid Chromatography (HPLC) coupled with the dissolution of a combination of fixed doses of four anti-tuberculous (Isoniazid, Pyrazinamide, Ethambutol Hydrochlorate, Rifampicine). The elaborated protocol was thereafter used to assess the quality of med...

The magnitude of problem with tuberculosis lies in the fact that one third of the world population is infected by Mycobacterium tuberculosis. Even in the 21st century, tuberculosis kills more people than any other infective agent. Definition of case of resistance--the case of resistant tuberculosis is precisely defined by the recommendations of the World Health Organization as primary, initial,...

Introduction: Aloe vera has anti-bacterial ability against Gram-positive and Gram-negative bacteria; however, study, especially in multidrug resistant strain of Mycobacterium tuberculosis, not been evaluated yet. This study aims to determine the potential as an antituberculosis drug-resistant strains tuberculosis. Method: Stages research include production ethanol extract vera, then testing phy...

BACKGROUND The first line anti-tuberculosis drugs isoniazid (INH), rifampicin (RIF) and pyrazinamide (PZA) continues to be the effective drugs in the treatment of tuberculosis, however, the use of these drugs is associated with toxic reactions in tissues, particularly in the liver, leading to hepatitis. Silymarin, a standard plant extract with strong antioxidant activity obtained from S. marian...

Tuberculosis of the foot is an uncommon entity and the reported incidence is 0.1% to 0.3%. The isolated tuberculosis of talonavicular joint is exceptionally rare. In tuberculosis of the foot and ankle, the presentation is usually nonspecific. The diagnosis of tuberculosis affecting foot is difficult, especially when it is isolated. In doubtful cases, diagnosis should be confirmed by histopathol...

Tuberculosis is an infectious disease caused by the bacteria Mycobacterium which has a rod shape and acid-resistant. The prolonged consumption of anti-tuberculosis drugs can cause serious side effects. Side effects from drugs, namely risk hepatotoxicity, marked increase in SGOT / SGPT value. This study aimed to determine relationship between duration use, dosage tuberculosis patients, had effec...

Efficient tuberculosis treatment requires the use of good quality medicines. The present study developed a method of dosage by High Performance Liquid Chromatography (HPLC) coupled with the dissolution of a combination of fixed doses of four anti-tuberculous (Isoniazid, Pyrazinamide, Ethambutol Hydrochlorate, Rifampicine). The elaborated protocol was thereafter used to assess the quality of med...

BACKGROUND Surveillance and effective management of drug resistance is important to sustaining tuberculosis (TB) control efforts. We aimed to determine resistance rates to first line anti tuberculosis drugs and to describe factors associated with the resistance to any of the first line anti tuberculosis drugs in Dar es Salaam Tanzania. MATERIALS Newly diagnosed, TB patients with neither histo...