Anti-microsomal (anti-Mic Ab) and anti-thyroperoxidase antibody activities (anti-TPO Ab) were compared by using commercially available radioassay kits. Sera were collected from 52 patients with Graves disease before and after administration of carbimazole (1-methyl-2-thio-3-carbethoxyimidazole). The two antibody concentrations were significantly correlated, both before treatment (r = 0.835, P l...

BACKGROUND Vitiligo is an acquired skin disorder characterized by depigmented maculae resulting from a reduction of the number and function of melanocytes. The etiopathogenesis of the disease is still unclear, but there is evidence that autoimmunity may be involved. OBJECTIVE The aim of this study was to determine the prevalence and significance of antinuclear (ANA) and thyroid peroxidase (an...

351 Prevalence of Thyroid Peroxidase Autoantibodies (ANTI-TPO) in Women with Autoimmune Connective Tissue Diseases (ACTD) Georgios Papadopoulos, MD, Anastasia Vakaloudi, PhD, Eirene Koutsika, MD, Ekarerini Anastasiou, MD, and Asimoula Koteli, MD. Immunology Laboratory, General Hospital Agios Pavlos, Thessaloniki, Greece. Background: Chronic autoimmune thyroiditis, manifested by positive test fo...

351 Prevalence of Thyroid Peroxidase Autoantibodies (ANTI-TPO) in Women with Autoimmune Connective Tissue Diseases (ACTD) Georgios Papadopoulos, MD, Anastasia Vakaloudi, PhD, Eirene Koutsika, MD, Ekarerini Anastasiou, MD, and Asimoula Koteli, MD. Immunology Laboratory, General Hospital Agios Pavlos, Thessaloniki, Greece. Background: Chronic autoimmune thyroiditis, manifested by positive test fo...

A full-length cDNA clone for human thyroid peroxidase (TPO) inserted into the mammalian cell expression vector pECE was stably transfected into Chinese hamster ovary (CHO) cells. Clones were assayed for human TPO mRNA, TPO protein, and TPO enzymatic activity. One subclone, expressing the highest TPO enzymatic activity, was used in further studies. FACS analysis of these cells preincubated in Ha...

BACKGROUND Insufficient function of the thyroid gland can cause low concentrations of thyroid gland hormones which are necessary for the proper development of the foetus brain, especially during the beginning of pregnancy. We determined the reference interval for TSH in the first trimester of pregnancy and the decision point for anti-TPO antibodies' positivity. METHODS We tested 5520 women fr...

351 Prevalence of Thyroid Peroxidase Autoantibodies (ANTI-TPO) in Women with Autoimmune Connective Tissue Diseases (ACTD) Georgios Papadopoulos, MD, Anastasia Vakaloudi, PhD, Eirene Koutsika, MD, Ekarerini Anastasiou, MD, and Asimoula Koteli, MD. Immunology Laboratory, General Hospital Agios Pavlos, Thessaloniki, Greece. Background: Chronic autoimmune thyroiditis, manifested by positive test fo...

patients with turner’s syndrome (ts) are at an increased risk of developing autoimmune thyroid disease (atd). the aim of this study was to determine the frequency of anti-thyroid peroxidase (anti-tpo) antibodies and atd in children and adolescent girls with ts. it also assessed the influence of karyotype on the development of thyroid disease. sixty eight patients with ts were compared with 68 a...

BACKGROUND The role of thrombophilia and thyroid autoimmunity in unexplained infertility (UI), implantation failure (IF) and recurrent spontaneous abortion (RSA) is controversial and poorly understood. METHODS From March, 2004 to January, 2007, 119 women were prospectively included: 32 oocyte donors, 31 patients with UI, 26 with IF and 30 with RSA. The IF and RSA groups presented normal preim...

351 Prevalence of Thyroid Peroxidase Autoantibodies (ANTI-TPO) in Women with Autoimmune Connective Tissue Diseases (ACTD) Georgios Papadopoulos, MD, Anastasia Vakaloudi, PhD, Eirene Koutsika, MD, Ekarerini Anastasiou, MD, and Asimoula Koteli, MD. Immunology Laboratory, General Hospital Agios Pavlos, Thessaloniki, Greece. Background: Chronic autoimmune thyroiditis, manifested by positive test fo...