We report here a relationship between intramolecular epitope spreading and the clinical onset of the endemic form of pemphigus foliaceus in a Brazilian community with a high prevalence and incidence of the disease. Also known as Fogo Selvagem (FS), this disease is characterized by severe skin blistering and pathogenic anti-desmoglein-1 (Dsg1) autoantibodies. These autoantibodies bind the Dsg1 e...

Systemic lupus erythematosus (SLE) is an autoimmune disease, but its etiology not completely understood. Recently, the microbiotas in nasal cavity and gut have been shown to be involved development of SLE, influence skin microbiota still unclear. Here, we demonstrated that NfkbizΔK5 mice treated with Staphylococcus aureus develop SLE-associated autoantibodies glomerulonephritis IgG deposition. ...

Bullous pemphigoid (BP) is the most common autoimmune blistering disease driven by autoantibodies targeting type XVII collagen (Col17, BP180), which mediates adhesion of basal keratinocytes to underlying basement membrane in epithelial tissues. Here, we evaluated therapeutic effects murine Fc fragment IgG2c-ABDEG (mABDEG), a derivative neonatal receptor (FcRn) inhibitor efgartigimod, experiment...

INTRODUCTION BRAF (v raf murine sarcoma viral oncogene homologue B1) is a serine-threonine kinase involved in the mitogen-activated protein kinase (MAPK) signalling pathway, known to be implicated in the production of pro-inflammatory cytokines.We have observed that sera from rheumatoid arthritis (RA) patients recognize the BRAF's catalytic domain, which encompasses amino acids 416 to 766. Here...

background: antiself humoral immune responses have been detected not only in classical autoimmune dis­eases, but autoantibodies have also been found in sera of patients suffering from chronic parasitic dis­eases. we aimed to investigate the role of fasciolosis as a trigger factor of autoimmune reactivity by searching some anti­bodies related to hepatobiliary systems, in patients with fasciolosi...

Abstract Linear childhood discoid lupus erythematosus (DLE) is a rare variant of DLE with linear distribution that preferentially occurs on the face and scalp children. We report case Blaschko's line his left upper arm 7‐year‐old Japanese boy 4‐year history disease. He was positive for anti‐single‐stranded DNA antibodies, but still showed no systemic symptoms during 3‐year follow‐up period. rev...

The objective of this study was to determine the prevalence, mutual associations, clinical manifestations, and diagnoses associated with serum autoantibodies, as detected using recently available immunoassays, in patients with autoimmune myositis (AIM). Sera and clinical data were collected from 100 patients with AIM followed longitudinally. Sera were screened cross-sectionally for 21 autoantib...

Cutaneous arteritis (CA) is a single-organ vasculitis that exclusively affects small to medium-sized arteries of the skin. Diagnosis depends on histological investigation with skin biopsy, which could be burdensome for both patients and clinicians. Moreover, pathogenesis CA remains unstudied, etiology-specific treatment has not yet been established. Herein, we engaged our proteome-wide autoanti...

In patients with systemic sclerosis (SSc), interstitial lung disease (ILD) is a factor in the decline of functional capacity up to disability and also leading cause death. Therefore, one most important tasks treatment this group not only detect involvement respiratory system, but predict likelihood its development. Objective : study possibility predicting development ILD advanced SSc. Material ...

BACKGROUND A previous pilot study showed a high frequency of anti-smooth muscle autoantibody in Omani blood donors and pregnant women. We conducted this larger-scale study to investigate the frequency and significance of several autoantibodies in healthy individuals from different regions of Oman. METHODS Sera obtained from 1537 healthy Omanis (1153 males and 384 females), ranging in age from...