ETHNOPHARMACOLOGICAL RELEVANCE Piper sarmentosum (Piperaceae) is a medicinal plant traditionally used by the Malays to treat headaches, toothaches, coughs, asthma and fever. AIM OF THE STUDY In order to establish the pharmacological properties of the leaf of this plant, studies were performed on anti-nociceptive and anti-inflammatory activities. MATERIALS AND METHODS The aqueous extract of ...

Background & Aim: Family Zingiberaceae is worldwide in   distribution. Plants of the zingiberaceae family are used in traditional   herbal folk medicine besides their uses in spices, cosmetic, ornamental, food   preservatives etc. In Uttarakhand the herbs grow from sub-tropical to   temperate region. Globba sessiliflora Simsrhizomes were collected at maturity stage in ...

Background & Aim: Family Zingiberaceae is worldwide in   distribution. Plants of the zingiberaceae family are used in traditional   herbal folk medicine besides their uses in spices, cosmetic, ornamental, food   preservatives etc. In Uttarakhand the herbs grow from sub-tropical to   temperate region. Globba sessiliflora Simsrhizomes were collected at maturity stage in ...

Background and objectives: Otostegia persica (Labiatae) is an endemic plant of Iran and is used for its anti-inflammatory properties in folk medicine of Sistan and Baluchestan province. The aim of the present study was to investigate the anti-nociceptive and anti-inflammatory effects of O. Persica different fractions and identification of the natural compounds...

The purpose of the present study was to evaluate anti-nociceptive effects of morphine, tramadol, meloxicam and their combinations in rats. Seventy male Wistar rats were divided into seven equal groups and randomly assigned to receive intraperitoneal saline (S) (control group, 1.0 mL kg-1), morphine (MO) (4.0 mg kg-1), tramadol (TR) (12.5 mg kg-1), meloxicam (ML)...

Although morphine is a gold standard medication, long-term opioid use is associated with serious side effects, such as morphine-induced hyperalgesia (MIH) and anti-nociceptive tolerance. Microglia-to-neuron signalling is critically involved in pain hypersensitivity. However, molecules that control microglial cellular state under chronic morphine treatment remain unknown. Here we show that the m...

Objective(s):Reduction of pharmacological effectiveness or tolerance appears following repeated administration of many analgesic drugs. We investigated tolerance to anti-nociceptive effects of orexin-A, an endogenous potent analgesic peptide using the hot-plate test.Materials and Methods:Orexin-A was microinjected ICV (intracerebroventricular) with an interval of 12 hr for 7 continuous days and...

Diabetic neuropathic pain, an important micro vascular complication in diabetes mellitus, has been recognized as one of the most difficult types of pain to treat. Lack of understanding of etiology involved, inadequate relief, development of tolerance and potential toxicity of classical anti-nociceptive agents warrants the investigation of newer agents to relieve this pain. The aim of the presen...