Aerva lanata is broadly utilized in urinary issues in Southern part of India as a source of Pashana bheda. A member of Amaranthaceae that is normally known as Gorakha ganja, it is usually located on mountains as weed. Many researches have been carried out to elicit the diuretic and anti-urolithic interest of this plant. It also has been verified for other pharmacological activities like anti-he...

Pseudotumour is a benign inflammatory lesion. Mycobacterial spindle cell pseudotumour (MSP) is a rare pseudotumour. It is a benign proliferation of spindle-shaped histiocytes containing acid-fast mycobacterium, commonly reported in immunocompromised patients. MSP is usually associated with mycobacterium avium complex (MAC). Here, we present the case of a 38-year-old gentleman with acquired immu...

Bacterial survival requires an intact peptidoglycan layer, a three-dimensional exoskeleton that encapsulates the cytoplasmic membrane. Historically, the final steps of peptidoglycan synthesis are known to be carried out by D,D-transpeptidases, enzymes that are inhibited by the β-lactams, which constitute >50% of all antibacterials in clinical use. Here, we show that the carbapenem subclass of β...

A series of novel 8-OMe ciprofloxacin (CPFX)-hydrazone/azole hybrids were designed, synthesized, and evaluated for their in vitro biological activities. Our results reveal that all of the hydrozone-containing hybrids (except for 7) show potency against Mycobacterium tuberculosis (MTB) H37Rv (minimum inhibitory concentration (MIC): <0.5 μM), which is better than the parent drug CPFX, and compara...

Pulmonary tuberculosis is rampant in some countries. The disease an outcome of infection by Mycobacterium and more common immunocompromised individuals. Furthermore, mycetoma or a fungal ball can develop cavitary lesions tuberculosis. present case rare presentation pulmonary with concomitant Aspergillus diabetic Indian male. A clinical examination strong laboratory radiological workup helped es...

dihydropyridines (dhps) with carboxamides in the 3 and 5 positions show anti-tuberculosis activity. the purpose of the present study was to synthesize new dhps that would possibly possess anti-tuberculosis activity. so a series of n-aryl-1,4-dihydropyridine-3,5-dicarboxamides (3-38) was prepared. they were screened as antitubercular agents against one type of fast growing mycobacterium (m. smeg...

BACKGROUND Long duration of treatment, side-effects of currently used anti-tubercular drugs and emergence of drug-resistant forms of Mycobacterium tuberculosis (MTB) warrants the need to develop new drugs to tackle the scourge of tuberculosis (TB). Garlic is an edible plant reported to have anti-tubercular activity. However, previous researches on anti-tubercular effect of garlic were focused m...

Mycobacterium aurum (M. aurum) is an environmental mycobacteria that has previously been used in studies of anti-mycobacterial drugs due to its fast growth rate and low pathogenicity. The M. aurum genome has been sequenced and assembled into 46 contigs, with a total length of 6.02Mb containing 5684 annotated protein-coding genes. A phylogenetic analysis using whole genome alignments positioned ...

In vitro anti-tubercular activity of a series 15 novel 2,3-dihydroquinazolin-4(1H)-one analogues were evaluated against Mycobacterium tuberculosis H37Ra (ATCC 25177 strain). Among the series, seven compounds showed moderate to good anti-TB with minimum inhibitory concentration (MIC) values ranging from 25.0–12.5 ?g/mL. Further, in silico experiments carried out identify probable ligand-protein ...