In this study the chemical composition, cholinesterase inhibitory property and anti-inflammatory activity of S. leriifolia Benth. essential oil was evaluated for the first time. GC and GC-MS analysis revealed the presence of camphor (10.5%), 1,8-cineole (8.6%), camphene (6.2%) and alpha-pinene (4.7%) as main constituents. S. leriifolia oil exhibited a promising antioxidant activity by DPPH assa...

Abstract Background In medicinal chemistry, indole and its derivative play an important role. Indole is gaining a lot of importance in chemistry due to physiological activity which includes anticancer, antitubercular, antimicrobial, antiviral, antimalarial, anti-inflammatory activities, antileishmanial agents, anti-cholinesterase, enzyme inhibitory. The spread antimicrobial resistance becomes t...

HIGHLIGHTS ASS2324 is a hybrid compound resulting from the juxtaposition of donepezil and the propargylamine PF9601N ASS2324 is a multi-target directed propargylamine able to bind to all the AChE/BuChE and MAO A/B enzymesASS2324 shows antioxidant, neuroprotective and suitable permeability propertiesASS2324 restores the scopolamine-induced cognitive impairment to the same extent as donepezil, an...

Cyperus platycaulis is used in folk medicine in Kano, northern Nigeria, for the treatment of cold, cough, (tuberculosis), chest congestion, asthma, sneezing, and catarrh. The tuberous fragrant herb (black species) was extracted using ethanol, chloroform, n-butane, and n-hexane, to determine the physico-chemical properties of the plant and the cytotoxicity of the extracts with reference to its a...

Meptazinol has been shown to have significant effects on neuromuscular transmission in the isolated rat phrenic nerve-diaphragm preparation. The response of the preparation to indirect electrical stimulation was increased in a concentration-dependent manner by meptazinol hydrochloride 2-32 micrograms ml-1. Meptazinol 0.5-2 micrograms ml-1 antagonized the effects the tubocurarine on this prepara...

Purpose: Cholinesterase inhibitors are the class of compounds which inhibit cholinesterase enzyme. These are used as drugs for symptomatic treatment of Alzheimer’s disease (AD). The present study, evaluate antibutyrylcholinestease property of ethanolic extract of Shorea robusta de oil cake (DOC). Method: Ellman’s method was used to determine the butyrylcholinesterase (BuChE) enzyme inhibitory a...

OBJECTIVE To determine whether (i) cholinesterase activity is increased in the saliva of patients with primary Sjogren's syndrome (pSS), (ii) increased levels of cholinesterase of lymphocyte origin could interfere with the secretory activity of submandibular acinar cells, and (iii) hydroxychloroquine at therapeutic doses could interfere with cholinesterase activity. METHODS The Ellman method ...