Citation: Xie L and Bourne PE (2015) Developing multi-target therapeutics to fine-tune the evolutionary dynamics of the cancer ecosystem. Multi-target therapies, either in combination or in sequential order, have been advocated to combat intrinsic and acquired resistance to anti-cancer drugs (Holohan et al., 2013; Yardley, 2013). However, the effectiveness of multi-target anti-cancer therapy in...

although the conventional therapies have obviously improved the conditions of patients with cancer, some mechanisms of resistance have led scientists to use alternative agents that can penetrate in most solid tumors. furthermore, the success of cancer therapies depends on limiting the uptake of toxins to normal tissues and their selectivity to malignant cells. the involvement of natural and gen...

urtica dioica is a perennial plant used as herbal medicine due to its many pharmacological and clinical effects. because of its antioxidant activity, it is widely used in traditional diabetes treatment but is also known as antimicrobial, anti inflammatory or anti prostate cancer agent. extensive studies have been conducted on different parts of this plant and their biological effects. here we r...

objective(s): the novel 7-hydroxycoumarinyl gallates derivatives are detected in many pharmaceutical compounds like anticancer and antimicrobial agents. whereas carbon nanotubes (cnts) have been discussed for nanomedicine applications and in particular as drug delivery systems. the capability of armchair (5, 5) swcnt -based drug delivery system in the therapy of anticancer has been investigated...

Ferula persica, is the well-known species of the genus Ferula in Iran and has two varieties: persica and latisecta. They have both been extensively used in traditional medicine for a wide range of ailments. A great number of chemical compounds including sesquiterpene coumarins and polysulfides have been isolated from this plant. Fresh plant materials, crude extracts and isolated components of F...

Objective(s): Lung cancer is the main leading cause of cancer death worldwide. Angiogenesis is the main step in proliferation and spreading of tumor cells. Targeting vascular endothelial growth factor (VEGF) is an effective approach for inhibition of cancer angiogenesis. Nanobodies (NBs) are a novel class of antibodies derived from the camel. Unique characteristics of Nbs like their small size ...

Despite diagnostic, preventive and therapeutic advances, growing incidence of cancer and high rate of mortality among patients affected by specific cancer types indicate current clinical measures are not ideally useful in eradicating cancer. Chemoresistance and subsequent disease relapse are believed to be mainly driven by the cell-molecular heterogeneity of human tumors that necessitates perso...

Geraniol is an acyclic monoterpenoid compound, which exists widely in aromatic plants. has antibacterial and anti-inflammatory effects. Recently, it been found that geraniol a strong effect on improving immune function anti-tumor. Many experimental evidences support good the treatment or prevention of different types tumors, such as breast cancer, lung liver pancreatic colon prostate etc. also ...