Mutational inactivation of p53 is a key player in the development of human cancer. Thus, retrieving the tumor suppressor activity of p53 gene is considered a novel strategy in cancer therapy. Current study aimed to investigate the anti-cancer potentials of botulinum toxin type-A (BTX-A) and captopril as a trial to shed light on effective anti-cancer therapy with lower side effects. Cytotoxic ef...

there is the need for new drugs with better action and lesser side effects. a lot of research is being undertaken to find out new plant drugs, their extraction and pharmacological evaluation. one of such plant is curcuma aromatica whichbelongs to the genus curcuma and reported to have high ethno-botanical values in traditional medicine. the present study evaluates comparative pharmacological ac...

abstract in the present study, eleven compounds (1-11) including nine alkaloids (1-9), one triterpenoid saponin (10) and one formamide (11) were isolated from talaromyces sp. lgt-2, an endophytic fungus from tripterygium wilfordi. their structures were determined based on nmr and esi-ms spectral data, as well as comparing with previous literature data. this is the first report of the isolation ...

background: artediffusin is a sesquiterpene lactone with an endoperoxide group which has been isolated from artemisia diffusa. artemisia has always been of great botanical and pharmaceutical interest and is useful in traditional medicines for the treatment of a variety of diseases and complaints. the aims of the present study were to evaluate the cytotoxic, mutagenic and anti-mutagenic activiti...

Breast cancer is the second main cause of death among women. The use of medicinal plants has been common in many countries since ancient times. The aim of this study was to evaluate the antioxidant and anti-proliferative potential of Achillea millefolium L. The antioxidant activity of the aqueous and hydroalcoholic extracts of Achillea millefolium L. leaf and flower was measured by DPPH and FRA...

curcumin is a natural polyphenolic compound with anti-cancer, anti-inflammatory, and anti-oxidation properties. low water solubility and rapid hydrolytic degradation are two challenges limiting use of curcumin as therapeutic agent. in the current study, the role of the bovine serum albumin (bsa), β-lactoglobulin and casein, as food-grade biopolymers and safe drug delivery systems, on the physic...

Bamboo is a perennial, woody grass, belonging to the Poaceae Family. Different bamboo species have been found therapeutic applications and studies shown that medicinal uses such as anti-cancer activity, anti-oxidant antimicrobial anti-diabetic anti-inflammatory anti-fertility activity antihypertensive. In this study, fermented was used for extraction of phytochemicals analysis their antioxidant...

The risk of human breast cancer is concerned to cumulative exposure of the breast cells to endogenous estrogens. Strategies aiming at reducing the production of estrogens may be useful for the prevention of estrogens-related breast cancer. Several natural products with plant origin have the potential value as chemo-preventive or therapeutic agents in cancer. Flavonoids, the natural polyphenol c...