Streptococci and actinomyces that initiate colonization of the tooth surface frequently coaggregate with each other as well as with other oral bacteria. These observations have led to the hypothesis that interbacterial adhesion influences spatiotemporal development of plaque. To assess the role of such interactions in oral biofilm formation in vivo, antibodies directed against bacterial surface...

To win the battle against resistant, pathogenic bacteria, novel classes of anti-infectives and targets are urgently needed. Bacterial uptake, distribution, metabolic efflux pathways antibiotics in Gram-negative bacteria determine what we here refer to as bacterial bioavailability. Understanding these mechanisms from a chemical perspective is essential for anti-infective activity hence, drug dis...

Bacteria form a biofilm that attaches the microbial population to solid surface, thus acting as barrier protect external stresses from bacterial community. In food industry, biofilms are believed be responsible for food-borne diseases and spoilages. This research was conducted characterize anti-quorum sensing (QS), anti-biofilm activity of crude extract, supernatant Actinobacteria isolates agai...

The study of lipopeptides and their related compounds produced by various living organisms from bacteria to marine invertebrates is fundamental interest for medicinal chemistry, pharmacology, practical clinical medicine. Using the principles retrosynthetic analysis linear cyclic peptides, pharmacological activity unique, unusual, rare fatty acids (FA) that are part natural was investigated. To ...

Treatment of neural cells with calix[n]arenes featuring sulphonate moieties and linked to Ag nanoparticles results in reduced reactive species. For Gram+ bacteria there is an inverse correlation between anti-bacterial activity and ROS reduction whereas for Gram- bacteria only calix[6]arenes bearing O-alkyl sulphonate functions act as ROS inhibitors and anti-bacterial agents.

Chytridiomycosis, caused by the fungus Batrachochytrium dendrobatidis (Bd), is a widespread disease of amphibians responsible for population declines and extinctions. Some bacteria from amphibians' skins produce antimicrobial substances active against Bd. Supplementing populations of these cutaneous antifungal bacteria might help manage chytridiomycosis in wild amphibians. However, the activity...