Objective(s): 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET-CT) is a well-used and established technique for lung cancer staging. Radiation therapy requires accurate target volume delineation, which is difficult in most cases due to coexisting atelectasis. The present study was performed to compare the 18F-FDG PET-CT with contrast enhanced computed tomogr...

Metronomic chemotherapy in combination with immunotherapy is an attractive approach in cancer therapy. The purpose of the present study was to investigate the anti-tumor effect of granulocyte-macrophage colony-stimulating factor (GM-CSF) in combination with metronomic paclitaxel (MET PTX) on Lewis lung carcinoma transplanted in mice. In the present study, tumor-bearing mice survival time and tu...

Positron emission tomography (PET) using the radiolabeled glucose analogue 18F-FDG allows uncovering glycolysis processes within cancer cells and reveals high value in diagnosis, staging, relapse and therapeutic response evaluation in several malignancies. Breast cancer presents considerable variability when it comes to 18F-FDG uptake, which results in different sensitivity and specificity valu...

There is an unmet need to develop imaging methods for the early and objective assessment of breast tumors to therapy. 3'-Deoxy-3'-[18F]fluorothymidine ([18F]FLT)-positron emission tomography represents a new approach to imaging thymidine kinase activity, and hence, cellular proliferation. We compared graphical, spectral, and semiquantitative analytic methodologies for quantifying [18F]FLT kinet...

Abstract Background Diagnosis of tumour thrombosis and differentiating it from benign are essential for managing patients, planning treatments, minimising unneeded anticoagulation therapy. Bland thrombi occur in both cancer non-cancer patients; bland can coexist. 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F - FDG PET/CT) is useful detecting diagnosing distinguish...

Renal cell carcinoma (RCC) is the most frequent renal tumor and the majority of patients are diagnosed with advanced disease. Tumor angiogenesis plays a crucial role in the development and progression of RCC together with hypoxia and glucose metabolism. These three pathways are strictly connected to the cell growth and proliferation, like a loop that is self-feeding. Over the last few years, th...

Ovarian cancer (OC) is the most fatal gynecological malignancy, and identifying reliable prognostic indicators can help guide therapeutic treatment. Various tumor marker-guided treatment regimens considerably improve patient prognosis with a better understanding of molecular underpinnings ovarian recurrence metastasis. Fluorine-18-fluorodeoxyglucose Positron emission tomography/computed tomogra...

OBJECTIVES To investigate fused multiparametric positron emission tomography/magnetic resonance imaging (MP PET/MRI) at 3T in patients with locally advanced cervical cancer, using high-resolution T2-weighted, contrast-enhanced MRI (CE-MRI), diffusion-weighted imaging (DWI), and the radiotracers [18F]fluorodeoxyglucose ([18F]FDG) and [18F]fluoromisonidazol ([18F]FMISO) for the non-invasive detec...

Whole-body Positron Emission Tomography/Computed Tomography (PET/CT) with [11C]and [18F]-labeled choline derivatives has emerged as a promising molecular imaging modality for evaluation of prostate cancer. 11C-choline and 18F-flurocholine PET/CT examinations have been shown to be effective for restaging of prostate cancer patients with biochemical disease recurrence after undergoing definitive ...