The PhoE porin of Escherichia coli is induced by phosphate deprivation and when purified, forms moderately anion-selective channels in lipid bilayer membranes. To further investigate the basis of anion selectivity, PhoE was chemically acetylated with acetic anhydride. Acetylation modified the mobility and staining characteristics of the PhoE porin on SDS-polyacrylamide gel electrophoresis but t...

INTRODUCTION. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ......... 582 ALKALI-CATION SELECTIVITY IN NONLIVING SySTEMS..... . . . . . . . . . . . . . . .. 583 ALKALI-CATION SELECTIVITY IN BIOLOGICAL SYSTEMS. . . . . . . . . . . . . . . . . . .. 587 THE ORIGIN OF ALKALI-CATION EQUILIBRIUM SELECTIVITY .. .. . .. . .... . " 589 ANION SELECTIVITY. . . • . . . . . ....

The mechanism of anion-catalyzed C–H silylation by R3SiCF3 reagents has been investigated using homogeneous TBAT-initiation, in situ and stopped-flow 19F NMR spectroscopy 2H-KIE, LFER, deuterium-labeled crossover, structure-selectivity quantitation (TMSCF3/TESCF3), carbene trapping, DFT-calculations. Analysis the kinetics reactions 1,3-difluorobenzenes (2), generation ArSiMe3 Me3SiF as a functi...

The voltage-dependent anion channel (VDAC) in the outer membrane of mitochondria serves an essential role in the transport of metabolites and electrolytes between the cell matrix and mitochondria. To examine its structure, dynamics, and the mechanisms underlying its electrophysiological properties, we performed a total of 1.77 μs molecular dynamics simulations of human VDAC isoform 1 in DOPE/DO...

Staphylotoxin channel appears to be predominantly anion-selective with non-linear and asymmetric current-voltage characteristics (CVC) at neutral pH. Increased salt concentrations induce linearity and asymmetry of CVC and loss of selectivity. At lower pH both the channel conductivity and anion selectivity increase. Higher temperatures raise the channel conductivity in parallel with the changes ...

A new series of noncyclic ionophores containing two to four furan units (Ia to IIIb) i.e. 1,1-difurylethane (Ia), 2,5-bis(methylfurfuryl)furan (IIa) and 1,1’ ethyledenebis[5-(methylfurfuryl)furan] (IIIa), 2,2-difurylpropane (Ib), 2,5-bis (dimethylfurfuryl)furan(IIb), 2,2’-isopropylidenebis[5-(dimethylfurfuryl)furan] (IIIb) have been synthesized by the condensation of furan with acetaldehyde and...

A series of non-cyclic polyethers with different end groups and chain length were used for the extraction of lithium salt from aqueous into various organic phases viz. Chloroform, Carbon tetrachloride, 1,2-dichloroethane, to study the influence of structural variations within the extractant molecule upon the extraction selectivity and efficiency. The ionophores used were viz. DEG (I), DEGDME (I...