BACKGROUND The pathomechanisms of atherosclerosis and vascular remodelling are under intense research. Only a few in vivo tools to study these processes longitudinally in animal experiments are available. Here, we evaluated the potential of micro-CT technology. METHODS Lumen areas of the common carotid arteries (CCA) in the ApoE-/- partial carotid artery ligation mouse model were compared bet...

The early phase of embryonic development involves a lot signaling and growth factor proteins that will influence the interactions among cells. Administration BSA (Bovine Serum Albumin) at beginning embryo can interferes organogenesis causing abnormalities in development. Administrations were expected to induce responses immune system, which be hoped mimicking stress on system caused by infectio...

There are a lot of reports and reviews about osteonecrosis of the talus (ONT), yet reports about the animal model of ONT to evaluate proper therapeutic approaches are rarely heard. In our study, a novel animal model was established. Pure ethanol was injected into the cancellous bone of sheep's talus. Macroscopic observation, X-ray, CT and histology were performed at two, four, 12 and 24 weeks p...

Mice represent the most commonly used species for preclinical in vivo research. While incisional and excisional acute murine wound models are both frequently employed, there is little agreement on which model is optimum. Moreover, current lack of standardization of wounding procedure, analysis time point(s), method of assessment, and the use of individual wounds vs. individual animals as replic...

Dr. Strauss is aware of the importance to the body of the mechanisms influencing the disposal of water, although his teleology is sometimes tongue-in-cheek. In discussing diurnal variations in urine flow, "the teleologic usefulness of a diminished output of urine during the usual time of sleep requires no comment." Approximately twice as much space is devoted to thirst, water, and the antidiure...

The only hope is education, yet the limitations placed on this solution are severe. The author feels that the rightful function of education is to fit the young "to participate in their culture and to preserve it"; social change must come from the adult community, not the schools. In addition, each culture is "to have considerable respect for the past and its achievements, to rely on scrutiny a...

We have developed a model system that recapitulates nearly all elements of native human skin biology. Currently, the available systems to study biology are limited animal models or other incomplete in vitro culture systems. Animal suffer from well known differences between and organism biology, while fail incorporate critical such as stromal immune cells. Our newly contains skin, allowing for s...

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OBJECTIVE Currently, no large animal model exists for surgical-experimental exploratory analysis of implantable hearing devices. In a histomorphometric study, we sought to investigate whether sheep or pig cochleae are suitable for this purpose and whether device implantation is feasible. METHODS Skulls of pig and sheep cadavers were examined using high-resolution 128-slice computed tomography...

PURPOSE The concept of biologic width forms a basis for successful peri-implant soft tissue integration around titanium implants. Therefore, the objectives of this review are to determine and critically evaluate the present knowledge about biologic width around implants and to establish future research trends. MATERIALS AND METHODS The literature was selected through several electronic databa...