نتایج جستجو برای: angiotensinergic

تعداد نتایج: 104  

Journal: :Pharmacological reviews 2015
Sadashiva S Karnik Hamiyet Unal Jacqueline R Kemp Kalyan C Tirupula Satoru Eguchi Patrick M L Vanderheyden Walter G Thomas

The renin angiotensin system (RAS) produced hormone peptides regulate many vital body functions. Dysfunctional signaling by receptors for RAS peptides leads to pathologic states. Nearly half of humanity today would likely benefit from modern drugs targeting these receptors. The receptors for RAS peptides consist of three G-protein-coupled receptors—the angiotensin II type 1 receptor (AT1 recept...

Journal: :American journal of physiology. Regulatory, integrative and comparative physiology 2004
Anna M D Watson Rasim Mogulkoc Robin M McAllen Clive N May

Central actions of angiotensin play an important role in cardiovascular control and have been implicated in the pathogenesis of hypertension and heart failure. One feature of centrally or peripherally administered angiotensin is that the bradycardia in response to an acute pressor effect is blunted. It is unknown whether after central angiotensin this is due partly to increased cardiac sympathe...

Journal: :American journal of physiology. Regulatory, integrative and comparative physiology 2012
Bing S Huang Roselyn A White Li Bi Frans H H Leenen

Central infusion of an angiotensin type 1 (AT(1)) receptor blocker prevents sympathetic hyperactivity and hypertension in Dahl salt-sensitive (S) rats on high salt. In the present study, we examined whether central infusion of a direct renin inhibitor exerts similar effects. Intracerebroventricular infusion of aliskiren at the rate of 0.05 mg/day markedly inhibited the increase in ANG II levels...

Journal: :Brain Research 2012
Ana Quênia Gomes da Silva Carlos Henrique Xavier Maria Jose Campagnole-Santos Sordaini M. Caligiorne Ovidiu C. Baltatu Michael Bader Robson Augusto S. Santos Marco Antônio P. Fontes

Previous evidence indicates that a balance between inhibitory gabaergic and excitatory angiotensinergic factors in the PVN is important for cardiovascular control. We investigated the cardiovascular response evoked from activation or blockade of GABA(A) receptors in the paraventricular nucleus (PVN), in transgenic rats with low brain angiotensinogen [TGR(ASrAOGEN)]. Brain Ang II and Ang-(1-7) l...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2006
Ramaswamy Ramchandran Takanobu Takezako Yasser Saad Linda Stull Bruno Fink Hirotsugu Yamada Sergey Dikalov David G Harrison Christine Moravec Sadashiva S Karnik

It is not clear whether endothelial cell (EC) activation by the hormone angiotensin II (Ang II) modulates contraction of vascular smooth muscle cells (VSMCs) in the vasculature and whether impairment of this regulation in vivo contributes to hypertension. Delineation of the actions of Ang II through the type 1 receptor (AT1R) on ECs in the blood vessels has been a challenging problem because of...

Journal: :Hypertension 2011
Justin L Grobe Beth A Buehrer Aline M Hilzendeger Xuebo Liu Deborah R Davis Di Xu Curt D Sigmund

Low-renin hypertension accounts for ≈ 25% of essential hypertensive patients. It is modeled in animals by chronic delivery of deoxycorticosterone acetate and excess dietary sodium (the DOCA-salt model). Previous studies have demonstrated that DOCA-salt hypertension is mediated through activation of the brain renin-angiotensin system. Here, we demonstrate robust metabolic phenotypes of DOCA-salt...

Journal: :American journal of physiology. Heart and circulatory physiology 2013
Adam J Case Shumin Li Urmi Basu Jun Tian Matthew C Zimmerman

Angiotensin II (ANG II) plays an important role in the central regulation of systemic cardiovascular function. ANG II-mediated intraneuronal signaling has been shown to be predicated by an increase in mitochondrial superoxide (O₂∙-), yet the source of this reactive oxygen species (ROS) production remains unclear. NADPH oxidase 4 (Nox4), a member of the NADPH oxidase family, has been reported to...

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