OBJECTIVE Monocyte recruitment and interaction with the endothelium is imperative to vascular recovery. Tie2 plays a key role in endothelial health and vascular remodeling. We studied monocyte-mediated Tie2/angiopoietin signaling following interaction of primary monocytes with endothelial cells and its role in endothelial cell survival. METHODS AND RESULTS The direct interaction of primary mo...

Angiotensin II–Mediated Vascular Inflammation: The Balance Between Vascular Endothelial Growth Factor and Angiopoietins To the Editor: Vascular endothelial growth factor (VEGF) is a potent angiogenic factor and plays a key role in postnatal angiogenesis in human pathophysiology, including cardiovascular disease. The activation of the renin-angiotensin system has been similarly implicated in the...

Our very existence depends on the air that we breathe, as well as the remarkable systems that have evolved to ensure that the oxygen we take into our lungs is efficiently delivered to the rest of the body via the bloodstream. When these systems begin to fail, life itself can become quite tenuous. Such failure occurs in pulmonary hypertension, a rare but serious disease whose pathophysiology rem...

KEY POINTS Combining nitric oxide (NO)-mediated increased blood flow with angiopoietin-1-Tie2 receptor signalling induces arteriolargenesis - the formation of arterioles from capillaries - in a model of physiological angiogenesis. This NO-Tie-mediated arteriolargenesis requires endogenous vascular endothelial growth factor (VEGF) signalling. Inhibition of VEGF signalling increases pericyte cove...

Angiopoietin-1 is implicated in the maturation and remodeling of the vascular network during embryo development and in adult life. Through its tyrosine kinase receptor Tie-2 it stimulates endothelial cells to migrate and change shape. Here we show that angiopoietin-1 elicits chemokinesis of endothelial cells by a phosphoinositide 3-OH kinase/son of sevenless-dependent modulation of Rac1 and Rho...

The angiopoietins comprise a small class of secreted glycoproteins that play crucial roles in the maturation and maintenance of the mammalian vascular and lymphatic systems. They exert their effects through a member of the tyrosine kinase receptor family, Tie2. Angiopoietin/Tie2 signaling is unique among tyrosine kinase receptor-ligand systems in that distinct angiopoietin ligands, although hig...

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