Balloon angioplasty revolutionized coronary revascularization; however, elastic recoil and restenosis caused by cellular proliferation are major drawbacks of angioplasty. Intracoronary stenting, which could tackle dissections and eliminate elastic recoil, became the next mode of intervention but was limited by stent thrombosis and increased neointimal hyperplasia, leading to in-stent restenosis...

Introduced 20 years ago,1 coronary artery stents have improved the safety and particularly the efficacy of percutaneous coronary interventions (PCIs).2 Abrupt vessel closure, complicating 6% to 8% of balloon angioplasty procedures, was associated with a 5% mortality, 40% rate of myocardial infarction (MI), and 40% rate of emergency coronary artery bypass grafting.3 Stents significantly reduced ...

Patients who undergo percutaneous transluminal coronary angioplasty (PTCA) for coronary artery disease are at risk for recurrence at the site of the procedure. Placement of stents as an adjunct to PTCA is one strategy to reduce recurrence. The use of various techniques to apply intracoronary radiation through local application of catheters or placement of radioactive stents (also known as intra...

It was not long ago that I was a medical student at McGill. I graduated in the class of 1996. When I started to do interventional work as a Cardiology Resident at McGill, we were well into the era of coronary intervention. Almost every balloon angioplasty was followed by the implantation of a stent, which had been shown to improve the immediate and long-term results of interventional therapy. L...

Many advances have been made in the percutaneous treatment of coronary artery disease during the past 30 years. Although balloon angioplasty alone is still performed, the use of coronary artery stents is much more common. Approximately 40 percent of patients treated with balloon angioplasty developed restenosis, and this was reduced to roughly 30 percent with the use of bare-metal stents. Howev...

Top Introduction Radiation Therapy for Restenosis References Renarrowing of a coronary artery (restenosis) at the site of earlier balloon angioplasty is in 1996 still a clinical problem, with an incidence of 30% to 50%. Despite 20 years of experimental and clinical research, the biology of restenosis is still not fully understood. These studies have, however, greatly enhanced our insight into t...

The current treatment for coronary restenosis following balloon angioplasty involves the use of a mechanical or a drug-eluting stent. Despite the high usage of commercially-available drug-eluting stents in the cardiac field, there are a number of limitations. This review will present the background ofrestenosis, go briefly into the molecular and cellular mechanisms of restenosis, the use of mec...

background: the incidence of restenosis in patients suffering from coronary artery disease after undergoing angioplasty is of paramount importance. accordingly, this study aimed to investigate factors affecting the time of the first incidence of restenosis in patients undergone angioplasty in the city of zanjan, iran.   methods: this retrospective cohort study was conducted on 421 patients who ...

Percutaneous coronary interventions (PCIs) are standard therapy for the treatment of atherosclerotic lesions of the coronary arteries. Since the introduction of rotational atherectomy (RA) in 1989, it has become established as a necessary adjunct to PCI in a small proportion of cases, notably calcified lesions. However, its use is hampered by the recurrent phenomenon of restenosis. The introduc...

The introduction of percutaneous transluminal coronary angioplasty (PTCA) by Andreas Gruentzig was a game changer for coronary revascularization (1). However, PTCA is associated with significant rates of acute closure and restenosis resulting from vascular recoil, neointimal hyperplasia, and negative remodeling. Bare-metal stents (BMS) effectively treat acute closure and limit restenosis by pre...