OBJECTIVE To determine whether androgen receptors affect the fatty acid profiles of neutral and polar lipids in human meibomian gland secretions. METHODS Meibomian gland secretion samples were obtained from both eyes of (1) women with complete androgen insensitivity syndrome, a condition characterized by dysfunctional androgen receptors, and (2) age-matched female and male controls. Samples w...

BACKGROUND Neither oral contraceptives (COC) nor metformin are an optimal modality for the long-term treatment of polycystic ovary syndrome (PCOS). The aim of this study was to evaluate whether a combination of both is beneficial over COC monotherapy. METHODS Altogether, 30 women were included in the study and 28 finished the protocol. The patients were randomly assigned to two groups treated...

Maternally derived yolk androgens affect many aspects of phenotypic development. To explore this phenomenon I injected clutches of American kestrels (Falco sparverius) with one of three different dosages of testosterone + androstenedione or with vehicle. Morphological measurements taken from nestlings 26 days after hatching showed no significant treatment effect. In 2007, nestlings with more yo...

Maternally derived yolk androgens affect many aspects of phenotypic development. To explore this phenomenon I injected clutches of American kestrels (Falco sparverius) with one of three different dosages of testosterone + androstenedione or with vehicle. Morphological measurements taken from nestlings 26 days after hatching showed no significant treatment effect. In 2007, nestlings with more yo...

Hair follicle cyclical regeneration is regulated by epithelial-mesenchymal interactions. During androgenetic alopecia (AGA), hair stem cells (HFSC) differentiation impaired deregulation of dermal papilla (DPC) secreted factors. We analyzed androgen influence on BMPs expression in DPC and their effect HFSC to lineage. Androgens downregulated BMP2 BMP4 spheroids. Addition restored alkaline phosph...

This study focused on inspecting the relationship between impulsivity traits, salivary dehydroepiandrosterone sulfate (DHEA-S) concentrations, and moderate alcohol consumption in healthy subjects. In previous studies, has been related to androgens. Limited research sulfated form of DHEA-S or impulsivity. Moderate can increase levels. Effects alcohol, androgens levels may depend age gender. The ...

Growth of the human breast cancer cell line MCF-7 is enhanced by androgens, but only at pharmacological concentrations. Although physiological concentrations of androgens translocate the androgen receptor into the nucleus, no mitogenic effects are observed. By contrast, pharmacological androgens translocate not only the androgen receptor but also the estrogen receptor, and at these high doses s...

BACKGROUND Cerebral venous sinus thrombosis is rare and can be promoted by various conditions. We report the case of cerebral venous thrombosis in a patient using androgens. CASE DESCRIPTION A 31-year-old man using androgens for bodybuilding was admitted for headache and vomiting. He had cerebral venous sinus thrombosis, but extensive examinations did not reveal any known cause. CONCLUSIONS...