Regucalcin (RGN) is a mammalian Ca2+-binding protein that plays an important role in intracellular Ca2+ homeostasis. Recently, RGN has been identified as a target gene for sex steroid hormones in the prostate glands and testis of rats and humans, but no studies have focused on RGN expression in bovine tissues. Thus, in the present study, we examined RGN mRNA and protein expression in the differ...

The mechanisms by which male sex hormones modulate cardiovascular function are a subject of contemporary interest. Several lines of evidence indicate that androgens can exert acute vasorelaxing effects. On the other hand, chronic exposure to androgens has been shown to promote increases in blood pressure and compromise renal function. In the present issue of Clinical Science, Malkin and co-work...

the androgen insensitivity syndrome is a heterogeneous disorder with a wide spectrum of phenotypic abnormalities, ranging from complete female to ambiguous forms that more closely resemble males. the primary abnormality is a defective androgen receptor protein due to a mutation of the androgen receptor gene. this prevents normal androgen action and thus leads to impaired virilization. a point m...

Nuclear import of the human androgen receptor was investigated by immunocytochemical analysis of androgen receptor deletion and substitution mutants, which were transiently expressed in COS-1 cells. The signal responsible for nuclear import is encoded by amino-acid residues 608-625 and is functionally similar to the bipartite nucleoplasmin nuclear-localization signal. Although the subcellular d...

Steroid androgen hormones play a key role in the progression and treatment of prostate cancer, with androgen deprivation therapy being the first-line treatment used to control cancer growth. Here we apply a novel search strategy to identify androgen-regulated cellular pathways that may be clinically important in prostate cancer. Using RNASeq data, we searched for genes that showed reciprocal ch...

Studies from this laboratory have shown that renal N-nitrosodimethylamine demethylase (NDMA demethylase), an enzyme responsible for the metabolism of NDMA, shows age- and sex-related differences and is modulated by testosterone. These results have been positively correlated with NDMA-induced mutagenicity and carcinogenicity studies; however, relatively large doses of testosterone (100 mg/kg or ...

Objective: To see how dose of Silymarin aqueous extracts affected prolactin hormone gene expression in pituitary glands and Androgen serum samples female experimental rats throughout nursing. Methods: 24 adult healthy, Two sets pregnant were created (12 each group) treated as follows for ten days postnatal. G 1 intubated orally distal water serving control while, 2 (200 mg\kg\day). Results: The...

Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders in women. It characterized by numerous hormonal and metabolic disturbances, among which hyperandrogenism, insulin resistance, as well disruption carbohydrate lipid metabolism play an important role. The study aimed to present PCOS, taking into account skin lesions often disorder. collected information concerns mechan...

preeclampsia is a major cause of morbidity and mortality during pregnancy. several independent investigators have demonstrated the association of androgens with hypertension. the main purpose of this study was to determine whether maternal levels of sex hormones, especially testosterone, are higher in patients with preeclampsia than in matched normotensive control subjects. serum levels of test...