Opening of mitochondrial ATP-sensitive (mitoKATP) channel with diazoxide induces an early phase (EP) of cardioprotection. It is unknown whether diazoxide also induces a delayed phase (DP) of cardioprotection. Because nitric oxide (NO) modulates ATP sensitivity of the KATP channel, we hypothesized that NO may play a role in diazoxide-induced cardioprotection. Diazoxide (1 mg/kg) was administered...

Gibberellic acid (GA) enhances the synthesis otf a-amylase andl ribonutclease in isolated aleurone layers andl this process is inhibited by abscisiin. Removal of gibberellic acid in mid-course of a-amylase productioni results in a slowing down of a-amylase synthesis, suggesting a continued requirement of GA for eiizyme synthesis. This is paralleled by a continuous requirement for RNA synthesis....

nM. Thus, pyridloxal-P is the principal B6 vitaimer in plasma. Durinig pyridoxine stupplemiienitation, mealn plasnma levels of the B6 vitaimers anid pyridoxic acidl increasedl to 655±122 aindl 222±55 nM, respectively. The plasma content of pyridoxal-P aind( pyricloxic acidl increased 6-7-fold anid thatt of pyridoxal, 12-fold, but the pyridloxiine level did niot increase. Isolatedlhepatocytes, 1...

System management, now mainly a manual process based on individual knowledge and experience of administrators, is now very time-consuming, inefficient, and error-prone. This paper proposes an open framework to design and implement self-managing systems that dramatically alleviates the burden of system administrators and improves the security and stability of systems. To be machineprocessable, s...