We describe a 20-year-old man diagnosed with a myelodysplastic syndrome (MDS), admitted to our hospital due to pancytopenia and fever of undetermined origin after myelosuppression with chemotherapy. Disseminated aspergillosis (DIA) was suspected when he developed skin and lung involvement. A rapidly growing mass was detected on the left neck area, during hospitalization. A thyroid ultrasound re...

Following lung transplantation for end-stage cystic fibrosis, two male patients presented with shortness of breath, peripheral blood eosinophilia and segmental lung collapse. At bronchoscopy, each had bronchial mucous plugging containing Aspergillus fumigatus. This finding was associated with a systemic eosinophilia and skin test positivity to Aspergillus. Augmented steroid therapy resulted in ...

Background Strongyloides stercoralis, a geohelminth which affects humans, has a cosmopolitan distribution in the tropical and subtropical areas but is sporadic in temperate countries like Romania. Acquired perforating disorders are a group of uncommon skin conditions characterized by transepidermal extrusion of dermal components, usually occurring in patients with chronic renal failure and/or d...

BACKGROUND Fungal infections remain a substantial cause of mortality in lung transplant (LTx) recipients, yet no comprehensive consensus guidelines have been established for antifungal prophylaxis and treatment of Aspergillus infection in these patients. METHODS A cross-sectional study surveyed the directors from 27 of 64 (45.5%) active LTx centers in the United States to examine clinical pra...

invasive aspergillosis is one of the leading causes of morbidity and mortality among solid organ transplant recipients, especially in lung transplantations. diagnosis of invasive aspergillosis is one of the current challenges due to nonspecific clinical symptoms and broad differential diagnosis. definitive diagnosis usually requires invasive procedures, including bronchoscopy and ctguided biopsy

in this study, 60 female, new zealand white rabbits were chosen and divided into 3 groups . the animals in group 1&2 were immunosuppressed with dexamethazone and cyclosporin a (cya) respectively. the animals in group 3 (control animals) were not immunosuppressed. in each group, half of the rabbits were infected intratracheally and the other half were infected intravenously with 4 conidia of asp...

The induced auxotrophy for p-aminobenzoic acid (PABA) resulted in a complete loss of virulence of Aspergillus fumigatus for normal as well as cortisone-treated mice. The PABA-requiring mutant of A. fumigatus survived in vivo for 4 to 7 days without causing any infection. However, it showed conditional virulence in animals receiving PABA in very small quantities. Repeated inoculations of the via...

Purpose: Patients with acute respiratory distress syndrome (ARDS) due to viral infection admitted at ICU are risk for secondary complications like invasive pulmonary aspergillosis. Our study evaluates severe ARDS COVID-19 associated aspergillosis a single center in Madrid, Spain. Materials and Methods: A retrospective chart review of patients two the five ICUs that were available Gregorio Maran...

KOH: potassium hydroxide INTRODUCTION Aspergillus sp, Candida sp, and zygomycoses can disseminate rapidly in an immunocompromised host, causing significant morbidity and mortality. Serum testing, tissue biopsy, and culture are used to confirm a suspected diagnosis, but waiting for results may delay initiation of life-saving treatment. We report a case of disseminated aspergillosis presenting wi...