Introduction Intercellular communication is essential for almost all physiological and pathological processes. Endothelial cell (EC)-derived exosomes, working as mediators intercellular information exchange, are involved in the pathophysiological mechanisms of atherosclerosis. However, effect inflamed endothelial exosomes on function macrophages (Mϕ) poorly defined. This study aims to unravel h...

Idiopathic pulmonary fibrosis (IPF) is characterized by chronic inflammation, severe scarring, and stem cell senescence. Stem cell-based therapies modulate inflammatory and fibrogenic pathways by release of soluble factors. Stem cell-derived extracellular vesicles should be explored as a potential therapy for IPF. Human amnion epithelial cell-derived exosomes (hAEC Exo) were isolated and compar...

The purpose of this study was to investigate the metabolic cost of wearing a prototype exoskeleton (EXO) while walking with a range of heavy loads, and to analyze the associated gait biomechanics. Ten Army enlisted men participated in the study. Oxygen consumption (VO2) and gait biomechanics were measured while Soldiers walked at 4.83 km/h and 0% grade under three realistic load weight configur...

BACKGROUND In eukaryotic cells, DNA polymerase delta (Poldelta), whose catalytic subunit p125 is encoded in the Pold1 gene, plays a central role in chromosomal DNA replication, repair, and recombination. However, the physiological role of the Poldelta in mammalian development has not been thoroughly investigated. METHODOLOGY/PRINCIPAL FINDINGS To examine this role, we used a gene targeting st...

exo-Silatranes involve cage structures where the nitrogen lone pair points away from the cage rather than into it. This distinguishes them from the well-established endo-silatranes. exo-Silatranes have not been observed experimentally, consistent with a significant benefit to silicon-nitrogen interactions inside the cages as suggested for endo-silatranes. Identifying examples of exo-silatranes ...

We investigate how the variation of obliquity (the axial tilt) a hypothetical exo-Earth is effected by presence satellite, an exo-Moon. Namely, we study analytically and numerically range changes if exo-Moon added to system comprised exo-Sun, exo-planets. say that impact stabilising upon addition decreases, while call destabilising increases as system. The problem considered in general setup. a...

Adriamycin and docetaxel are two agents commonly used in treatment of breast cancer, but their efficacy is often limited by the emergence of chemoresistance. Recent studies indicate that exosomes act as vehicles for exchange of genetic cargo between heterogeneous populations of tumor cells, engendering a transmitted drug resistance for cancer development and progression. However, the specific c...

Cryptococcus neoformans is a common environmental yeast and opportunistic pathogen responsible for 15% of AIDS-related deaths worldwide. Mortality primarily results from meningoencephalitis, which occurs when fungal cells disseminate to the brain from the initial pulmonary infection site. A key C. neoformans virulence trait is the polysaccharide capsule. Capsule shields C. neoformans from immun...

Nucleotide incorporation by the herpes simplex virus type 1 DNA polymerase catalytic subunit (pol) is less faithful than for most replicative DNA polymerases, despite the presence of an associated 3'- to 5'-exonuclease (exo) activity. To determine the aspects of fidelity affected by the exo activity, nucleotide incorporation and mismatch extension frequency for purified wild-type and an exo-def...