Introduction Although the therapy for Behçet’s disease (BD) has improved since infliximab was approved for refractory retinochoroiditis therapy in Japan, the exact pathogenesis of BD remains unclear. Our recent genome-wide association study has identified the IL10 and IL23RIL12RB2 loci as susceptibility genes for BD, in addition to HLA-A*26 and B*51. rs1495965 is located in the intergenic regio...

Several neurodegenerative diseases are linked to defects in brain cholesterol metabolism. The brain comprises only ~6% of total body weight but contains 25% of cholesterol in the body. Unlike phospholipids, which are synthesized in both cell bodies and axons of neurons, cholesterol synthesis is restricted to cell bodies. Thus, efficient mechanisms exist for delivery of cholesterol to axons for ...

OBJECTIVE To examine whether parenting styles or practices were associated with children's television (TV) viewing. METHODS A total of 431 parent-child dyads (10- to 11-year-old children) from Bristol, United Kingdom, were included. Child and parent TV viewing were self-reported and categorized as <2, 2 to 4, or >4 hours/day. Children reported maternal parenting style (authoritarian, authorit...

Iran is one of the world's arid regions and exposed to dust particles in the air. This is important in spatial and temporal terms as well as the affects human health. In this paper a day when due to the amount of dust particles visibility reduces to 5,000 m is considered the dusty day. In the spatial and temporal analysis of dusty days 38 synoptic stations were studied. In order to conduct data...

Iran is one of the world's arid regions and exposed to dust particles in the air. This is important in spatial and temporal terms as well as the affects human health. In this paper a day when due to the amount of dust particles visibility reduces to 5,000 m is considered the dusty day. In the spatial and temporal analysis of dusty days 38 synoptic stations were studied. In order to conduct data...

We report on a detailed experimental study of the electron transport anisotropy in HgTe (013) quantum well 22 nm width directions [100] and [031¯] as density function n. The is absent at minimal near charge neutrality point. increases with increase n reaches about 10% when Fermi level within first subband H1. There sharp (up to 60%) second E2. conclude that effect due small intra-subband anisot...

Introduction FMF is a monogenic autoinflammatory disease with recurring episodes of fever and serositis attacks. FMF is associated with mutations in pyrin. On the other hand mutations in a molecule in the same pathway, cryopyrin, is characterized by inflammatory features involving the inner ear as well. A study has suggested the involvement of cochlea in Behçet disease, which is a polygenic aut...

When intact cells (HeLa S-3, mouse 3T3 fibroblasts, hen erythrocytes) are incubated with the rifamycin SV derivative AF/OI3, which is widely used as a potent inhibitor of mammalian DNA-dependent RNA polymerases, a rapid and extensive disintegration of the plasma membrane takes place. This cell disruption results, for example, in hemolysis of the erythrocytes at concentrations above 50 JLg/ml, i...