BACKGROUND A decreased expression of glutathione peroxidase mRNA, an antioxidant enzyme, was previously observed in thyroid anaplastic carcinomas. METHODS To clarify the expression of antioxidant-related enzymes in thyroid anaplastic carcinomas, the expression levels of catalase, copper and zinc superoxide dismutase and manganese superoxide dismutase mRNA in 85 benign and malignant thyroid ti...

Somatostatin (SRIH) analogs can suppress the proliferation of human differentiated thyroid carcinoma cell lines that express SRIH receptors (SSTRs) demonstrated by radioligand binding analysis. Five distinct human SSTR subtypes (hSSTR1-5) that bind native SRIH exhibit diverse affinities to a wide range of SRIH analogs. Reverse transcriptase-PCR amplification of ribonucleic acids (RNAs) obtained...

BACKGROUND Thyroid malignancies are a heterogeneous group oftumours which show considerable variability in biological behaviour, histological appearances and response to therapy. Thyroid cancer is uncommon and represents only 1% of all malignancies. Objective was to determine the prevalence of malignancy in patients presenting with goitre. This prospective, observational study was conducted at ...

OBJECTIVES To review our results with elective superior mediastinal dissections for thyroid carcinomas. STUDY DESIGN Retrospective review. METHODS We searched operative case logs for all patients with thyroid carcinoma treated with an elective superior mediastinal dissection by the senior author (Y.D.) during a 6-year period. Charts were reviewed for demographic information and pathologic r...

Thyroid squamous cell carcinoma is very rare. At present, it limited to case reports. Since the thyroid follicular epithelium non-squamous epithelium, how primary (SCC) of occurs still a controversial issue. Hashimoto’s thyroiditis (HT) considered be an independent risk factor for cancer, under basis HT, tumor cells evolve and develop papillary (PTC), particularly de-differentiate into SCC elus...

AIM To study the expression of p53 tumour suppressor gene in anaplastic carcinomas arising from thyroid papillary carcinomas. METHODS Formalin fixed, paraffin wax embedded tissues from four cases of anaplastic carcinomas associated with thyroid papillary carcinomas were studied by immunohistochemistry with two different p53 monoclonal antibodies. RESULTS The anaplastic component showed nucl...

type of midline neck masses in children. Though usually benign, 1% of cysts may undergo neoplastic change. The most common histological subtype is papillary carcinoma (80%) followed in order of frequency by mixed follicular-papillary, squamous, follicular, anaplastic, and hurthle-cell carcinoma (1). The synchronous occurrence of thyroglossal duct carcinoma and thyroid carcinoma in the thyroid g...

OBJECTIVE The aim of our studies was to determine whether the phenotype of the anaplastic thyroid carcinomas is dominant or recessive. In fact, it is hypothesized, on the basis of epidemiological and pathological data, that undifferentiated thyroid carcinomas are derived from differentiated tumours through a mechanism of tumour progression. DESIGN Cell hybrids have been generated by cell fusi...