Kounis syndrome is an allergy-associated acute coronary syndrome, which develops secondary to mast cell activation in coronary arteries due to hypersensitivity or anaphylactoid reaction (1). The triggering factors may be various drugs, food, environmental exposure, and intracoronary stents (2–4). In this case report, an extraordinary case of Kounis syndrome (acute myocardial infarction with con...

Aprotinin is widely used to prevent bleeding, inhibit systemic inflammatory response and reduce blood transfusions after cardiac surgery. Because it is a bovine protein, aprotinin can induce hypersensitivity reactions. We report a case of fatal anaphylactoid reaction to primary aprotinin exposure in a woman who was admitted for mitral valve replacement. The possibility of anaphylactic reaction ...

Since the introduction in 1979 of intravenous acetylcysteine (Parvolex) as an antidote for overdosage of paracetamol the National Poisons Information Service and the manufacturer have been notified of 38 adverse reactions that were anaphylactoid in nature and 19 accidental overdoses. The most common feature of the anaphylactoid reaction to normal dosage was rash; other features reported include...