AIM To identify the serum biomarkers of prostate cancer (PCa) by protein chip and bioinformatics. METHODS Serum samples from 83 PCa patients and 95 healthy men were taken from a mass screening in Changchun, China. Protein profiling was carried out using surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF MS). The data of spectra were analyzed using two bio...

Prostate cancer (PCa) is currently the most frequently diagnosed malignancy in the western countries. It is more prevalent in older men with 75% of the incident cases above 65 years old. After radical prostatectomy, approximately 30% of men develop clinical recurrence with elevated serum prostate-specific antigen levels. Therefore, it is important to unravel the molecular mechanisms underlying ...

In this paper a pose invariant face recognition using neuro-fuzzy approach is proposed. Here adaptive neuro fuzzy interface system (ANFIS) classifier is used as neuro-fuzzy approach for pose invariant face recognition. In the proposed approach the preprocessing of image is done by using adaptive median filter. It removes the salt pepper noise from the original images. From these denoised images...

INTRODUCTION Pain has been pointed out as one of the concerns of cardiac surgery patients. Acute pain management has been a challenge for health professionals and several regiments have been described. We designed this study to evaluate the effectiveness of pain control with patient-controlled analgesia (PCA) versus conventional nurse-controlled analgesia (NCA) during the postoperative period i...

Face recognition has become a valuable and routine forensic tool used by criminal investigators. It is an important area of computer vision research and has gained significant interest in recent years. Efforts in improving security, such as automatic surveillance and the use of biometrics in identification, are partly responsible for this increased interest. However, several challenges remain i...

Metastatic dissemination is a feature of most cancers including prostate cancer (PCa), and is the main cause of treatment failure and mortality. The aim of the study is to explore the mechanisms of PCa metastasis and to search for potential prognostic markers using proteomics. Two-dimensional fluorescent differential gel electrophoresis (2D-DIGE) was used to quantify proteins in normal prostate...

BACKGROUND Systematic approaches to functionally identify key players in microRNA (miRNA)-target networks regulating prostate cancer (PCa) proliferation are still missing. OBJECTIVE To comprehensively map miRNA regulation of genes relevant for PCa proliferation through phenotypic screening and tumor expression data. DESIGN, SETTING, AND PARTICIPANTS Gain-of-function screening with 1129 miRN...

PURPOSE Genetic variations among prostate cancer (PCa) patients who underwent radical prostatectomy (RP) and pelvic lymph node dissection were evaluated to predict lymph node invasion (LNI). Exome arrays were used to develop a clinicogenetic model that combined clinical data related to PCa and individual genetic variations. MATERIALS AND METHODS We genotyped 242,186 single-nucleotide polymorp...