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Two recent papers in Critical Care discuss the use of echinocandins in general [1], and anidulafungin in particular [2], during continuous renal replacement therapy (CRRT). Being highly protein bound and predominantly nonrenally eliminated drugs, echinocandins are barely removed by convection and thus require no dose adjustment during CRRT. Based on scarce literature data, González de Molina an...

Sir, Biju et al. w1x reported the case of an ESRD patient on a treatment with the AT II antagonist losartan who developed breathlessness, agitation, tachycardia, and hypertension after about 1 h of haemodialysis. Since this episode happened 943 Nephrol Dial Transplant (2002) 17: 943

Haemodialysis (HD)-associated anaphylactic and anaphylactoid reactions are found to be a complex problem, and though they have been well-documented in literature, a number of unexplored aspects remain. Anaphylaxis is a severe, life-threatening, generalized or systemic form of hypersensitivity. The clinical diagnosis is based on case history and physical examination, and includes symptoms of air...

BACKGROUND/AIMS With advanced anticoagulation, many institutions operate continuous renal replacement therapy (CRRT) circuits longer than manufacturers' recommendations. This extended use may change hemodiafilter performance and clearance properties. However, hemodiafilter performance over time has not been assessed. We investigated solute clearance over time in modeled CRRT. METHODS In vitro...