Microglia have long been noted to be present and activated in Alzheimer brain. Demonstrations that these microglia are associated with the specific lesions of Alzheimer disease-Aβ plaques and neurofibrillary tangles-and that these microglia overexpress the potent proinflammatory cytokine interleukin-1 led to the recognition of a potential pathogenic role for these cells in initiation and progre...

BACKGROUND Despite the outbreak in dental science, oral and dental complications in Alzheimer are of the unsolved problems. It is assumed that tumor necrosis factor-α, which is a key factor in Alzheimer, has a relation with periodontal complications in patients with Alzheimer disease. The present study evaluated the effect of chronic periodontitis on serum levels of tumor necrosis factor-α in A...

objective(s): alzheimer's disease (ad) is a neurodegenerative disorder in elderly patients. decrease in cholinergic neurotransmission is the main known cause in the pathophysiology of the disease. improvement and potentiation of the cholinergic system could be beneficial for treatment of the ad. acetylcholinesterase inhibitors such as donepezil can enhance the duration of action of acetylc...

........................................................................................................................................ .iii Acknowledgements.......................................................................................................................vii List of Tables.........................................................................................................

CT was used to document temporal lobe atrophy in 39 patients who were diagnosed clinically as having Alzheimer disease; the results were compared with those from 29 healthy elderly control subjects who were matched for age and education. The diagnosis of Alzheimer disease was made according to clinical criteria consistent with those specified by an NINCDS workshop. These included detailed medic...

Objetivo: Analisar a influência da resistência à insulina no prognóstico doença de Alzheimer. Revisão bibliográfica: A Alzheimer é um processo neurodegenerativo, caracterizado pela presença marcadores patológicos placas β-amilóide. tem função neuromoduladora e cérebro atua na sobrevivência dos neurônios, produção energia, plasticidade sináptica expressão gênica. Estudos recentes revelaram que c...

EL-Kordy EA1*, Alanazi AD2, Ali SS3, Makhlouf MMM4 and Rabah SO5 1Department of Histology, Faculty of Medicine, Tanta university, EgyptShaqra University, Saudi Arabia 2Department of Biological Sciences, Faculty of Science and Humanities, Shaqra University, Saudi Arabia 3Department of Anatomy, Faculty of medicine, King Abdul Aziz university, Saudi Arabia 4Department of Laboratories, Faculty of a...

Clostridium thermocellum wild-type strain YS is an anaerobic, thermophilic, cellulolytic bacterium capable of directly converting cellulosic substrates into ethanol. Strain YS and a derived cellulose adhesion-defective mutant strain, AD2, played pivotal roles in describing the original cellulosome concept. We present their draft genome sequences.

BACKGROUND Dietary n-3 polyunsaturated fatty acids improve brain functioning in animal studies, but there is limited study of whether this type of fat protects against Alzheimer disease. OBJECTIVE To examine whether fish consumption and intake of different types of n-3 fatty acids protect against Alzheimer disease. DESIGN Prospective study conducted from 1993 through 2000, of a stratified r...