Fernando Cebola Lidon*1, Maria da Graça Barreiro2 1Grupo de Disciplinas de Ecologia da Hidrosfera, Faculdade de Ciências e Tecnologia, Quinta da Torre, 2825–114 Caparica, Portugal Phone: 351212948543; Fax: 351212948543; Email: [email protected] 2Departamento de Fisiologia Vegetal, Estação Agronómica Nacional, Avenida da Republica Nova Oeiras, 2784–505 Oeiras, Portugal. Phone: 351214403500; Fax: 35...

This workshop will differ from other conferences on aluminum in that the participants will identify and discuss major unresolved/contrcversial issues related to aluminum that warrant future research and suggest research approaches. The key participants addressing each issue will prepare a written summary addressing their issue in advance of the workshop for presentation to the entire delegation...

Although chronic aluminum neurotoxicity has been well established, the mechanism of the toxicity has not been elucidated yet. In order to simplify the study of the aluminum neurotoxicity, we employed the pulse exposure of cultured rat cortical neurons to 250 microM aluminum-maltol for 1 h at the early stage (6 h after plating), which resulted in abnormal distribution of neurofilament L (NFL) an...

background: iron, manganese, and aluminum are three abundant metals on earth and their concentrations have increased in aquatic environments as a result of natural and industrial activities. this study was undertaken to report the median acute toxicity (lc50) and accumulation of the sub-lethal concentration (10% 96-h lc50) of iron (fe), manganese (mn) and aluminum (al) in kutum (rutilus kutum) ...

BACKGROUND Aluminum is considered to be a relatively safe metal for humans. However, there are some reports that aluminum can be toxic to humans and animals. In order to estimate the toxicity of aluminum with respect to humans, we measured the aluminum concentration in urine of aluminum-handling and non-handling workers and investigated the relationships between their urinary aluminum concentra...

BACKGROUND During the last years, human newborns have been overexposed to biologically reactive aluminum, with possible relevant consequences on their future health and on their susceptibility to a variety of diseases. Children, newborns and particularly preterm neonates are at an increased risk of aluminum toxicity because of their relative immaturity. DATA SOURCES Based on recent original p...

Whilst being environmentally abundant, aluminum is not essential for life. On the contrary, aluminum is a widely recognized neurotoxin that inhibits more than 200 biologically important functions and causes various adverse effects in plants, animals, and humans. The relationship between aluminum exposure and neurodegenerative diseases, including dialysis encephalopathy, amyotrophic lateral scle...

The chemical forms (species) of aluminum in blood plasma and brain extracellular fluid are considered, as they are the candidates for brain aluminum uptake and efflux. The blood-brain barrier is the primary site of brain aluminum uptake. The mechanism of brain uptake of aluminum transferrin, long thought to be mediated by transferrin-receptor mediated endocytosis, requires further investigation...

Even though aluminium is not considered to be a heavy metal like lead, silver, arsenic and cadmium, it can be toxic when taken in excessive amounts and even in small amounts if deposited in the brain. Glutathione, a major antioxidant in the cells, so its depletion weakens the tissue resistance to oxidant. Glutathione is the sulfhydryl (-SH) antioxidant, antitoxin and enzyme cofactor which plays...