Background: The efficiency of in vitro maturation (IVM) has remained low despite extensive effort to understand the culture conditions. This study investigated the effect of cumulus cells and meiotic inhibitors on oocyte developmental competence in the presence of Alpha Lipoic acid (ALA) Materials and Methods: Mouse germinal vesicle oocytes were considered in cumulus-denuded oocytes (CDOs) and ...

The availability of an active substance through the skin depends basically on two consecutive steps: the release of this substance from the vehicle and its subsequent permeation through the skin. Hence, studies on the specific properties of vehicles, such as their rheological behavior, are of great interest in the field of dermatological products. Recent studies have shown the influence of the ...

Introduction: This study evaluated the effects of pretreatments with melatonin (MT), and Alpha Lipoic acid (ALA) on lopinavir/ritonavir (LPV/r) -induced serum levels of creatinine (Cr), urea (U), uric acid (Ua) and kidney levels of malondialdehyde (MDA), superoxide dismutase (SOD), glutathione (GSH) and catalase (CAT) in male albino rats. Effects of treatments with MT and ALA were also evaluate...

introduction: epilepsy is a chronic neurological disorder in which patients experience spontaneous recurrent seizures and deficiency in learning and memory. although the most commonly recommended therapy is drug treatment, some patients do not achieve adequate control of their seizures on existing drugs. new medications with novel mechanisms of action are needed to help those patients whose sei...

Alpha lipoic acid has both hydrophilic and hydrophobic properties is widely dispersed in cellular membranes the cytoplasm. It one of most powerful antioxidants for cells. The current research looked at possible therapeutic benefits alpha acid) a male rat model D-galactose-induced brain aging. G1 normal as control group, G2 animals were given 200 mg/kg bw.IP. daily D-gal group 30 days, G3 100 mg...

R-alpha-Lipoic acid is found naturally occurring as a prosthetic group in alpha-keto acid dehydrogenase complexes of the mitochondria, and as such plays a fundamental role in metabolism. Although this has been known for decades, only recently has free supplemented alpha-lipoic acid been found to affect cellular metabolic processes in vitro, as it has the ability to alter the redox status of cel...

Metabolic changes during kidney and liver disease can induce increased production of oxygen radicals that play an important role in the progression damage appearance comorbidities. In study reported here, effect alpha-lipoic acid (ALA) on chemiluminescence (CL) TBARS determination microsomes isolated from rat was analyzed. Oxidative stress induced by subjecting samples (1 mg protein) to ascorba...

The role that antioxidants play in the process of carcinogenesis has recently gained considerable attention. alpha-Lipoic acid, a naturally occurring disulfide molecule, is a powerful antioxidant that reportedly exerts beneficial effects in patients with advanced cancer by reducing the level of reactive oxygen species and increasing glutathione peroxidase activity. In this study, we examined ch...

Alpha-lipoic acid (ALA) is a naturally-occurring compound that has shown promising antioxidant and anti-inflammatory effects in experimental and human studies. The aim of this study was to assess the efficacy of ALA in the management of patients with diabetes mellitus (DM).We searched Medline (via PubMed), EBSCO, Scopus, and Web of Science for relevant randomized controlled trials. Data o...

In the present study, the authors examined whether treating streptozotocin-induced diabetic rats with the combination of alpha-lipoic acid and fidarestat, an aldose reductase inhibitor, can promote the formation of dihydrolipoic acid in diabetic animals and thereby enhance the efficacy of alpha-lipoic acid as monotherapy toward preventing diabetic vascular and neural dysfunction. Treating diabe...