BACKGROUND Mucosal or oral tolerance, an established method for inducing low-risk antigen-specific hyporesponsiveness, has not been investigated in vascularized composite allograft (VCA) research. We studied its effects on recipient immune responses and VCA rejection. METHODS Lewis rats (n = 12; TREATED) received seven daily intrajejunal treatments of 5 × 10(7) splenocytes from semiallogeneic...

c Fig. 2. Confocal microscope showed a: normal FDP tendon b: allografts before implantation c: allograft treated with CHG d: allografts in control group Improvement of Flexor Tendon Reconstruction Using Carbodiimide Derivatized Hyaluronic Acid and Gelatin Modified Intrasynovial Allografts +Zhao, C; Sun, Y-L; Ikeda, J; Kirk, R L; Thoreson, A R; Moran, S L; An, K-N; Amadio, P C + Mayo Clinic, Bio...

We retrospectively reviewed 40 hips in 36 patients who had undergone acetabular reconstruction using a titanium Kerboull-type acetabular reinforcement device with bone allografts between May 2001 and April 2006. Impacted bone allografts were used for the management of American Academy of Orthopaedic Surgeons Type II defects in 17 hips, and bulk bone allografts together with impacted allografts ...

OBJECTIVES Cryopreserved valve allografts used in congenital cardiac surgery are associated with a significant cellular and humoral immune response. This might be reduced by removal of antigenic cellular elements (decellularization). The aim of this study was to determine the immunologic effect of decellularization in a rat allograft valve model. METHODS Brown Norway and Lewis rat aortic valv...

Structural bone allografts are widely used in the clinic to treat critical sized bone defects, despite lacking the osteoinductive characteristics of live autografts. To address this, we generated revitalized structural allografts wrapped with mesenchymal stem/progenitor cell (MSC) sheets, which were produced by expanding primary syngenic bone marrow derived cells on temperature-responsive plate...

Pedicles of skin which lacked a lymphatic drainage were raised on the backs of rats in order to study the importance of afferent lymphatics in sensitization by skin allografts. Although allografts transplanted to the alymphatic pedicles enjoyed a prolonged survival, they contracted progressively from about 3 wk after transplantation and were reduced eventually to small scars. In contrast, autog...

BACKGROUND Biostatic (nonvital) tissue allografts have been used for temporary replacement as well as to trigger, stimulate, and ensure space for the regeneration of a recipient's own tissues. Examples of biostatic allografts routinely used in clinic are bone, tendons, skin, and amniotic membrane. A characteristic feature of biostatic allografts is the lack of living cells. In the recipient's b...

Background: Regulatory T cells have been suggested to have a protective role against acute rejection in allograft recipients. However, there is little information available about their contribution to chronic rejection process. The role of transforming growth factor-beta 1 (TGF- β1) as a profibrogenic and/or immunoregulatory cytokine in renal allografts is also controversial. Objectives: To eva...

Abstract Early diagnosis and treatment of immune rejection is critical for face transplants (vascularized composite allografts, VCA). VCA diagnosed by histologic evaluation skin biopsies, yet repeated biopsies are a considerable aesthetic problem. Sentinel flaps, fasciocutaneous radial forearm have been used remote-site monitoring, but the concordance between tissues during remains unclear. Wit...