allergen immunotherapy involves the administration of gradually increasing quantities of specific allergens to patients with ige-mediated conditions until a dose is reached that is effective in reducing disease severity from natural exposure. in the present study we evaluated a period of six years immunotherapy allergic rhinitis and allergic asthma patients with positive skin prick test of comm...

Peanut allergy is an IgE-mediated, persisting immune disorder that is of major concern worldwide. Currently, no routine immunotherapy is available to treat this often severe and sometimes fatal food allergy. Traditional subcutaneous allergen immunotherapy with crude peanut extracts has proven not feasible due to the high risk of severe systemic side effects. The allergen-specific approaches und...

PURPOSE OF REVIEW The present review updates current findings on long-term clinical and immunological outcomes after cessation of allergen immunotherapy for allergic respiratory disease. RECENT FINDINGS Recent studies have shown that allergen immunotherapy has sustained disease-modifying effects that persist for years after discontinuation. This is in contrast to the effects of antiallergic d...

Allergen-specific immunotherapy is the primary pathogenetically substantiated method for treating allergic diseases.
 This treatment decreases severity of clinical symptoms, has disease-modifying effects, and prevents disease progression, asthma development, spread sensitization. A complex interaction between various cells innate adaptive immunity mediates immunological tolerance driven by...

Precision medicine is a medical model aiming to deliver customised healthcare - with medical decisions, practices, and/or products tailored to the individual patient informed but not directed by guidelines. Allergen immunotherapy has unique immunological rationale, since the approach is tailored to the specific IgE spectrum of an individual and modifies the natural course of the disease as it h...

Background Peanut is one of the most common foods responsible for food-induced anaphylaxis in adults. Unfortunately, commonly used allergen-specific immunotherapy has not been successful for the treatment of food allergy because of the high risk of serious side-effects. Therefore, chemically modified allergen extracts with improved safety characteristics are being investigated for its potential...

BACKGROUND A patient's knowledge of his/her allergic condition and treatment is a key factor in adherence and effectiveness. METHODS To assess patients' understanding of allergy and acceptance of allergen immunotherapy on the basis of (i) information given by their physician at the time of prescription and (ii) a new communication template viewed some months later, we performed an Internet-ba...

Food allergies encompass a range of disorders ranging from being an inconvenience to even causing fatalities, mainly due to anaphylaxis. A large number of individuals are affected and this presents great health and economic implications. However as yet, apart from dietary avoidance, effective treatment strategies are practically non-existent. The immune environment related to allergen-tolerance...

OBJECTIVE To evaluate the safety of an abbreviated course of injections of allergen extracts (rush immunotherapy) for the treatment of dogs with atopic dermatitis. ANIMALS 30 dogs with atopic dermatitis examined at a veterinary dermatology referral practice for treatment with allergen-specific immunotherapy. PROCEDURE A catheter was placed in a vein in each dog. Dogs were constantly observe...

PURPOSE Allergen-specific immunotherapy is the only currently available treatment to modify the natural history of allergic rhinitis (AR). If patients are polysensitized, it is difficult to identify the allergen causing the allergic symptoms. We evaluated the effectiveness of immunotherapy against house dust mites (HDMs) in AR patients polysensitized to both HDMs and seasonal allergens. METHO...