background: considering the increasing incidence of coronary artery stenosis and its related complications, the importance of its etiology and inconsistent reports we aimed to determine the relationship between oxysterol, serum levels and severity of coronary atherosclerosis and effect of statins on oxysterol.  methods: a total of 85 patients referred to taleghani hospital, tehran, iran during ...

introduction: a factor known to cause thrombophilia in women with recurrent pregnancy loss (rpl) is the a1298c polymorphism of methylenetetrahydrofolate reductase gene (mthfr). this study aimed to determine the association between rpl and this polymorphism in iranian patients. methods: in this case-control study, 30 patients with a previous history of two or more consecutive unexplained abortio...

background and aims. the aim of the present study is to determine the incidence of mthfr c677 t and a1298c mutations in iranian patients with cleft lip and/or cleft palate. materials and methods. we screened 61 iranian patients with cleft lip and/or cleft palate for mutations in the two alleles of mthfr gene associated with cleft lip and/or palate: a1298c and c677t, using polymerase chain react...

nitrate is one of the major sources of nitrogen for the growth of plants. it is taken up by plant roots and transported to the leaves where it is reduced to nitrite in the. the main objective of this research was to investigate stimulatory effects of sodium nitrate, potassium nitrate, ammonia and urea on the production/generation of the nitrate reductase mrna in triticum aestivum plants. the pl...

the thioredoxin system, comprising thioredoxin (trx), thioredoxin reductase (trxr) and nadph, is one of the major cellular antioxidant systems, implicated in a large and growing number of biological functions. trx acts as an oxidoreductase via a highly conserved dithiol/disulfide motif located in the active site ( trp-cys-gly-pro- cys-lys-). different factors are involved in the regulation of t...

background: to study methaemoglobin content and nadh-methaemoglobin reductase activity of three human erythrocyte genotypes (hbaa, hbas and hbss).materials and methods: studies to ascertain methaemoglobin concentration and level of nadh-methaemoglobin reductase activity of three human erythrocyte genotypes (hbaa, hbas and hbss) were carried out in forty-three (43) healthy male participants of c...

benign prostatic hyperplasia (bph) is a non-malignant enlargement of the prostate gland. itis a leading disorder of the elderly male population. excessive production of dihydrotestosteronehas been implicated in this pathological condition. steroidal 5α-reductase is a membrane boundnadph dependent enzyme which is responsible for the conversion of testosterone (t) todihydrotestosterone (dht). the...

thioredoxins (trxs) are small ubiquitous oxidoreductase proteins with two redox-active cys residues in a conserved active site (wcg/ppc) that regulate numerous target proteins via thiol/disulfide exchanges in the cells of prokaryotes and eukaryotes. the isoforms ostrx23 with a typical active site (wcgpc) and ostrx20 with an atypical active site (wctpc) are two  trx h- type isoforms in rice that ...

background: it is believed that environmental and genetic factors may be responsible for autism. methylenetetrahydrofolate reductase (mthfr) and its gene polymorphisms have been shown to be implicated as risk factors in autism. objectives: to analyze mthfr c677t polymorphism (rs1801133) in autistic patients. materials and methods: this study was carried out in 2014 and 2015 in northern iran. on...