We developed a one-pot, two-stage synthetic route to substituted 4-aminoquinolines involving an imidoylative Sonogashira coupling followed by acid-mediated cyclization. This three-component reaction affords pharmaceutically valuable 4-aminoquinolines in a one-pot procedure from readily available starting materials. The reaction tolerates various substituents on the arene as well as the use of s...

Four-component reactions between amino alcohols, aldehydes, isocyanides and thiols proceed rapidly under microwave or conventional heating at 60 ◦C in methanol. The reaction is successful with a wide range of components and gives access to potentially drug-like products containing amine, amide and thioether functionality in moderate to excellent yield. The reaction conditions are also applicabl...

The potential of continuous flow technology to streamline the synthesis, purification and postmodification reactions isocyanides is reported.

Highly substituted cyclopentenes can be accessed rapidly from isocyanides, aldehydes and malononitrile or ethyl cyanoacetate (AB2C2) using DABCO as a catalyst under solvent-free conditions at 40 °C within 30 min.

Dehydration of N -formamides to isocyanides using p -toluen sulphonyl chloride, sodium hydrogen carbonate in aqueous micelles is reported.

An efficient manganese(II)/O2-promoted oxidative radical cascade reaction was developed for the modular synthesis of multi-substituted isoquinolines from easily accessible vinyl isocyanides and boronic acids.