The ongoing Ebola outbreak in West Africa is the largest and most complicated that the world has even seen. Since it was first identified in the forested regions of south eastern Guinea in March, it has spread to Liberia, Sierra Leone, and Nigeria and has now been declared a “public health emergency of international concern” by the World Health Organization. Ebola virus is one of a group of zoo...

Bushpigs and warthogs are natural reservoir hosts of African swine fever virus (ASFV) in the wild, showing no clinical signs of disease when infected with the same highly virulent isolates of ASFV that induce rapid, haemorrhagic death in domestic pigs. In contrast to domestic pigs, infection of bushpigs with Malawi isolate results in low levels of virus replication and lymphocyte apoptosis with...

Dengue virus, the causative agent of dengue fever (DF) and more severe forms of the disease – dengue haemorrhagic fever (DHF) and dengue shock syndrome (DSS) – can infect a number of different types of cells. While monocytes and macrophages are considered to be primary target cells driving the pathology of the disease, numerous studies have implicated the liver as a site of dengue virus replica...

A virus belonging to the Flaviviridae group causes dengue haemorrhagic fever. Dengue presenting as acute liver failure is rare. Dengue is endemic in India. The last epidemic of dengue occurred in Delhi in 2003. During this epidemic, 2185 confirmed cases of dengue were reported. Dengue virus serotypes 2 and 3 were responsible for this epidemic. A 19-yr-old male presented to our hospital with the...

INTRODUCTION Lassa fever is an acute arena viral haemorrhagic fever with varied neurological sequelae. Sensorineural hearing loss is one of the rare complications which occur usually during the convalescent stage of the infection. CASE PRESENTATION The cases of two female patients aged 19 and 43 years old, respectively, with clinical features suggestive of Lassa fever and confirmed by immunos...

An epidemic of dengue haemorrhagic fever occurred in Delhi during 1988. A total of 21 paediatric patients with dengue haemorrhagic fever/dengue shock syndrome were evaluated from September to November 1988. All the patients had fever, restlessness, ecchymotic spots and ascites. Pleural effusion occurred in 19 patients (90%), and 18 (86%) exhibited each of the following: vomiting, thrombocytopen...

Introduction: Lassa fever is an acute viral zoonotic illness caused by Lassa virus, an arenavirus known to be responsible for a severe haemorrhagic fever characterized by fever, muscle aches, sore throat, nausea, vomiting, and chest and abdominal pain. The virus exhibits persistent, asymptomatic infection, with profuse urinary virus excretion in Mastomysnatalensis, the ubiquitous and highly com...

background: lassa fever is an acute, virulent viral haemorrhagic illness with high morbidity and mortality rates. its awareness remain low in sub urban or rural community. this study was carried out to assess the awareness of lassa fever of a rural community in the south western part of nigeria. methodology: a descriptive cross sectional study of 122 respondents prior to a sensitization seminar...