This analytical method for easier determination of codeine in human plasma is based on "high-performance" liquid chromatography for separation and the natural fluorescence of codeine for detection. Codeine is extracted from alkalinized plasma with a mixture of hexane and dichloromethane, and the extract is further purified and chromatographed. The method can be used for routine assay of codeine...

BACKGROUND Finafloxacin is a novel 8-cyano-fluoroquinolone under investigation for treatment of urinary tract infection. METHODS Urinary concentrations and urinary bactericidal titers (UBT) of finafloxacin 200- and 800-mg single doses in 6 healthy volunteers were measured up to 48 h. UBT were determined for a reference strain and 9 selected clinical uropathogens at the pH of native, acidified...

Terak feronikel dihasilkan sebagai produk samping dari produksi feronikel. terak mempunyai potensi bahan baku beberapa komponen berharga karena komposisinya melalui proses bertahap. Tujuan penelitian ini adalah untuk mengetahui pengaruh pemanggangan campuran dan Na2CO3 sebelum leaching air panas presipitasi menghasilkan endapan silika. Proses dengan penambahan telah dilakukan pembentukan natriu...

The cytoplasmic pH (pHin) of Enterococcus hirae growing at pH 9.2 was maintained at about 8.1. Membrane-permeating amines such as ammonia alkalinized the pHin from 8.1 to 9.0 at a high concentration and induced K+ extrusion. The pHin alkalinization was transient; the pHin fell from 9.0 to the original value of pH 8.1, at which point K+ extrusion ceased, and remained constant. Cells accumulated ...

We report a common methodology for determining three antiarrhythmic drugs: disopyramide, lidocaine, and quinidine. Alkalinized serum and internal standard (p-chlorodisopyramide) are extracted into dichloromethane, the organic phase is evaporated, and the redissolved residue is injected onto a reversed-phase column (micron Bondapack C18). Quantitation is via peak-height ratios of analyte vs inte...

The present assay was developed for quantifying midazolam in plasma of patients hospitalized in intensive-care units or undergoing anesthesia and receiving many other drugs as well. Plasma samples are alkalinized with NaOH and midazolam is extracted into n-hexane. The organic phase is evaporated and reconstituted in n-butyl acetate, and the midazolam is quantified by gas-liquid chromatography w...

The anticholinesterase drug galanthamine is obtained from alkalinized serum by repeated liquid--liquid extraction. The resulting extract is approximately 100 times concentrated with respect to the original sample. Quantitative determination of galanthamine is performed with normal-phase liquid chromatography using a mixture of dichloromethane--n-hexane and ethanolamine as an eluent. Phenacetin ...

This method for determination of haloperidol in plasma is based on "high-performance" isocratic liquid chromatography with the use of a C8 bonded reversed-phase column at room temperature. Haloperidol and the internal standard (chloro-substituted analog) are extracted from alkalinized plasma into isoamyl alcohol/heptane (1.5/98.5 by vol) and back-extracted into dilute H2SO4. The aqueous phase i...

say. J Clin Endocrinol Metab 27: 973-990, 1967 16. 13. Brecher G, Cronkite EP: Morphology and enumeration of human blood platelets. J Appl Physiol 3: 365-377, 1950 14. Baumgartner HR: Eine neue Methode zur Erzengung von Thromben 17. durch gesielte uberdehnung der Gefasswant. Z Ges Exp Med 137: 227-249, 1963 15. Stemerman MB, Spaet TH, Pitlick F, Cintron J, Lejnieks I, Tiell ML: 18. The pattern ...