A major obstacle to the development of effective treatment of Alzheimer's disease (AD) is successfully delivery of drugs to the brain. We have previously identified a series of benzothiazole phosphonate compounds that block the interaction of amyloid-β peptide with amyloid-β binding alcohol dehydrogenase (ABAD). A selective and sensitive method for the presence of three new benzothiazole ABAD i...

Current strategies for the treatment of Alzheimer's disease (AD) involve tackling the formation or clearance of the amyloid-beta peptide (Aβ) and/or hyper-phosphorylated tau, or the support and stabilization of the remaining neuronal networks. However, as we gain a clearer idea of the large number of molecular mechanisms at work in this disease, it is becoming clearer that the treatment of AD s...

fifteen microsatellite markers were employed to evaluate genetic relationships among different iranian species of crocus spp. (c. sativus, c. haussknechtii, c. cancellatus, c. speciosus, and c. caspius) from ten geographical regions (ghaen, gonabad, estahban, ferdows, veresk, reno, ali abad, kali abad, neka, and eslam abad). of these, 12 primers revealed polymorphism among crocus spp. average p...

T H E U C I U N D E R G R A D U A T E R E S E A R C H J O U R N A L F a c u l t y M e n t o r

In a Perspective accompanying Abad-Franch and colleagues, Lorenz von Seidlein, Alexander Kekulé, and Daniel Strickman discuss the importance of developing effective strategies to minimize mosquito-borne transmission of human diseases.

BACKGROUND Since Pars Abad district had been known as a focus of visceral leishmaniasis (VL) in Ardabil Province but the prevalence of the disease in nomadic tribes has not been determined, thus, this study was conducted. METHODS This descriptive cross-sectional study was conducted on children up to 12yr old of nomadic tribes from Pars Abad County, Ardabil Province, Iran in 2015. For each ind...

In the acute setting, the majority of patients affected by uncomplicated acute type B aortic dissection (ABAD) can be managed with medical therapy. In these patients, inhospital outcome is generally acceptable, with mortality rates of 1-10% (1,2). However, long-term outcomes in this group is less positive, with a mortality rates reported as 2025% within 3 years. Predictors of long-term complica...

the ali-abad porphyry copper deposit is located in the central iranian magmatic belt. as a result of subduction magmatism, oligo-miocene leucogranitoid rocks have intruded into conglomerates of lower cretaceous age. due to contact metamorphism the following mineral assemblage has occurred in the altered conglomerate: garnet (andradite-grossular) + epidote+ quartz + calcite + pyrite skarnificati...

We show that there may be a Milliken-Taylor ultrafilter with infinitely many near coherence classes of ultrafilters in its projection to ω, answering a question by López-Abad. We show that k-coloured Milliken-Taylor ultrafilters have at least k + 1 near coherence classes of ultrafilters in its projection to ω. We show that the Mathias forcing with a Milliken-Taylor ultrafilter destroys all Mill...