Film dosage forms containing metronidazole (MZ) were prepared from natural polysaccharides, such as pullulan (PUL) or sodium alginate (ALG), without heating or controlling the pH. The release profiles of MZ from the films were investigated. In the absence of a drug, the casting method resulted in the polysaccharide forming a circular film, and the presence of MZ affected film formation. The thi...

Water-soluble fluorescent colloidal quantum dots (QDs) have been widely used in some biological and biomedical fields, so the interaction of QDs with biomolecules recently attracts increasing attention. In this paper, CdTe quantum dots modified by a natural biopolymer based on polyacrylamide (PAAm) grafted onto sodium alginate (Alg-g-PAAm) were synthesized in an aqueous solution. Then, the bind...

The construction of multilayered films with tunable properties could offer new routes to produce biomaterials as a platform for 3D cell cultivation. In this study, multilayered films produced with five bilayers of chitosan and alginate (CHT/ALG) were built using water-soluble modified mesyl and tosyl–CHT via layer-by-layer (LbL) self-assembly. NMR results demonstrated the presences of mesyl (2....

Chondrocyte dedifferentiation has been noted in osteoarthritic cartilage, but the contribution of this phenomenon is poorly understood. Interleukin (IL)-1beta, the major pro-inflammatory cytokine found in osteoarthritic synovial fluid, induces the dedifferentiation of cultured articular chondrocytes, whereas E-series prostaglandins (PGE) are capable of inducing cell differentiation. Since PGE(2...

The green synthesis of supported noble metal nanoparticles is now the most exciting field for various catalytic applications as well as biomedical applications. In this paper we report a novel synthesis method of a polymer consisting of silver nanoparticles (AgNPs) using immobilized microorganisms in alginate beads. Microorganisms present in the polymer reduce aqueous AgNO3 to AgNPs which get t...

Polyelectrolyte multilayers (PEMs) composed of two natural polysaccharides-chitosan (Chi) and alginate (Alg) were deposited by Layer by layer (LbL) assembly on top of biocompatible poly(lactide-co-glycolide) (PLGA) nanoparticles (NPs). Folic acid (FA) or FA grafted poly(ethylene glycol) (PEG-FA) were covalently bounded to the PEMs via carbodiimide chemistry. The assembly of biocompatible PEMs w...

In the recent past, nanobiotechnology field has grown up tremendously with more applications because synthesis process will be practically possible techniques. Since, plant-derived biosynthesis of silver nanoparticles is superior since its eco-friendly, cost-efficient, speedy in nature. Alginate-based biodegradable nanocomposite films were prepared Celosia cristata leaf extracts (CC-AgNPs) and ...

In this work, a biohydrogel based on alginate and dynamic covalent B-O bonds, derived composites, has been evaluated for wound healing applications. particular, phenylboronic acid–alginate (PBA-Alg) complex was synthesized by coupling 3-aminophenylboronic acid onto alginate, used to prepare varied concentrations of hydrogels silicate-based nanocomposites in PBS. The resulting were characterized...

Extended Abstract Calcium carbonate (CaCO3) is one of the most abundant biominerals in nature and investigated at the laboratories, as well. CaCO3 has abundant industrial applications such as filler materials, bleaching agents, opacity reducer, paper filling, and biomedical applications such as drug delivery and orthopaedic– traumatology. For example, carbonate apatite acts as bioceramic implan...

PURPOSE This article describes preparation and characterization of beads of alginate containing probiotic bacteria of Lactobacillus acidophilus DMSZ20079. METHODS Fourteen formulations using different alginate (ALG) and CaCl2 concentrations as well as hardening times were prepared using extrusion technique. The prepared beads were characterized in terms of size, morphology, encapsulation effi...