AIMS It was investigated whether the allele A9 of the dopamine transporter gene (DAT1; SLC6A3) is associated with alcoholism, delirium tremens (DT), alcohol withdrawal seizures (AWS), or the daily alcohol intake. METHODS A group of 102 healthy subjects and 216 alcoholics, including 97 patients with a history of mild withdrawal symptoms, 65 with a history of AWS and 83 with a history of DT wer...

Periodic brain stimulation, particularly in the limbic system, at stimulus intensities initially too low to produce any behavioural or EEG effects, progressively produces EEG changes, motor automatisms, and eventually convulsions, an effect called kindling. Data are presented and reviewed that suggest that the severity of alcohol withdrawal symptoms progressively increases over years of alcohol...

PAX-6 gene promoter polymorphism, alcohol dependence history and CT were determined in the group of 68 alcoholics. We found negative correlation between numbers of PAX-6 gene promoter B (AC)m (AG)n repeats and atrophy of the brain and the cerebellum. Occurrence of these lesions was correlated with a decrease of alcohol tolerance, withdrawal symptoms--especially delirium tremens.

Alcohol withdrawal is a clinical state characterized by symptoms such as tremors, tachycardia, sweating, nausea and vomiting, headache, malaise, insomnia, grand mal convulsions amongst others. Patients typically present acutely with history of recent cessation or reduction heavy alcohol use after long period repeated, persistent use. It may feature perceptual disturbances illusions hallucinatio...

We determined zinc, copper, magnesium, and calcium concentrations by atomic absorption spectrophotometry in the plasma of 30 patients hospitalized for treatment of seizures during a period of alcohol withdrawal. Those patients who developed delirium tremens or a prolonged hallucinatory state had significantly higher plasma copper concentrations (P = 0.026), significantly lower zinc concentratio...

T seriousness of alcohol withdrawal and its widespread occur­ rence in the 166 Veterans Administration hospitals in the 1960’s was the principal reason this pivotal study was conducted. The important work by Kaim and colleagues has endured over the years, because alcohol withdrawal still is common, potentially life threatening, and often not recognized and treated promptly and effectively. Kaim...

OBJECTIVE To evaluate the effect of acute postoperative alcohol withdrawal on survival of vascularized fibular grafts for mandibular reconstruction. DESIGN Retrospective case series of 17 consecutive patients. MAIN OUTCOMES MEASURE Relation between flap survival and alcohol withdrawal. RESULTS Flap survival rate was 25% for patients who experienced delirium tremens and 85% in the other pa...

Alcohol dependence is an increasing and pervasive problem. Alcohol withdrawal symptoms are a part of alcohol dependence syndrome and are commonly encountered in general hospital settings, in most of the departments. Alcohol withdrawal syndrome ranges from mild to severe. The severe complicated alcohol withdrawal may present with hallucinations, seizures or delirium tremens. Benzodiazepines have...

The abuse of alcohol gives rise to a wide variety of neurological disorders. However, the mechanism by which alcohol produces its effect is quite different in each of them. One group of symptoms is due to the toxic effects of alcohol-per.. se;. anatb r; io t1ie withdrawal of the drug after a period of prolonged inebriation; and still others, to the effects of ^maTnulrhion or -derangement of liv...