the aim of the present study was to evaluate vitamin c (vc) as a potent natural antioxidant to mitigate the genotoxic effects of arsenic trioxide and sodium fluoride in swiss albino mice in vivo. the study was divided into eight groups consisting of control treated with normal saline (group i), group ii, iii, iv, v, vi, vii and the vc group with only vitamin c (500 mg/kgbw). arsenic trioxide (4...

PURPOSE Individuals with oculocutaneous albinism are predisposed to visual system abnormalities affecting the retina and retinofugal projections, which may lead to reduced visual acuity and Infantile Nystagmus Syndrome (INS). Due to absence of an established mammalian animal model, mechanisms underlying INS remain elusive. In this study, we screened wild-type mice of varying pigmentation for oc...

The aim of the present study was to investigate the toxicological effects of medicinal herb extract of Momordica charantica, Emblica officinalis, Tribulus terrestris and Trigonella foenum graecium in Albino mice. The herbal extract was prepared by maceration of the fruits of these plant, procured locally. The extracts were dried and store separately. These were reconstituted separately with car...

Mutagens in the environment may represent a long-term risk for ecosystems. The reproductive potential of populations can be affected by alterations in the fecundity and offspring viability caused by germ cell mutations. Despite the ecological relevance of these effects, there are few studies on germ cell mutagenicity in natural populations. Biomphalaria glabrata was chosen for this study becaus...

the aim of the present study is to evaluate the effect of ethanolic extract of leaves of leptadenia reticulata leaves (lelr) against dalton’s ascitic lymphoma (dal) in swiss albino mice. dal cells were injected intraperitoneally (106 cells/mouse) to the mice. two days after cells injection the animals were treated with 200 mg/kg of lelr for 8 days. five-fluorouracil (20 mg/kg) was used as refer...

Food intake triggers convulsions in fasted BALB/c mice and Wistar albino rats treated with antimuscarinic drugs, scopolamine or atropine. Inbred strain studies have yielded considerable information regarding genetic influences on seizure susceptibility and factors contribute to epileptogenesis in rodents. This study, therefore, investigated sensitivity to antimuscarinic-induced seizures in C57B...

PURPOSE The C57BL/6ByJ and BALB/cByJ inbred strains of mice are, respectively, susceptible and resistant to oxygen-induced retinopathy (OIR). The purpose of this work was to investigate the genetic control of the retinal avascular area in mouse OIR using a mapping cross. METHODS The central retinal avascular area was measured on postnatal day 16 (P16) in C57BL/6ByJ, BALB/cByJ, 101 (C57BL/6ByJ...

The effect of coccoid forms of a vaculating cytotoxin A positive Helicobacter pylori strain on Mus musculus (Swiss mice) and Rattus norvegicus (Albino rats) was studied. Two groups of Swiss mice and Albino rats were used. The first group of mice and rats was orally inoculated with coccoid forms of Helicobacter pylori, whereas, the second group of mice and rats were untreated and used as a contr...

Sesbania sesban (L.) Merr. Syn.-S. aegyptiaca Pers. (Hindi-Jaint, Jayanti; Englishcommon sesban, Aegyptian Rattle pod) belonging to family-leguminoceae, is a soft wooded, fast growing, short lived shrub,1.8-6 m. high found cultivated throughout the plains of India up to an altitude of 1200 m. and has been reported by Saha[17] et al., 1961; Chaudhury[5], 1966 and Malhi & Trivedi[11], 1972. Bhadu...