The development of small-molecule modulators of protein-protein interactions is a formidable goal, albeit one that possesses significant potential for the discovery of novel therapeutics. Despite the daunting challenges, a variety of examples exists for the inhibition of two large protein partners with low-molecular-weight ligands. This review discusses the strategies for targeting protein-prot...

We report three cases of successful treatment of proliferating deep infantile hemangiomas with topical timolol 0.5% gel-forming solution (GFS) used two to three times daily. We recommend considering timolol as an initial option for small, deep facial hemangiomas that are not causing functional compromise or complications but may have an unsatisfactory cosmetic appearance. In our experience, alb...

We study the effect of vacuum polarization in nuclear reactions of astrophys-ical interest. This effect has the opposite sign compared to the screening by the atomic electrons. It is shown that vacuum polarization further increases the longstanding differences between the experimental data of astrophysical nuclear reactions at very low energies and the theoretical calculations which aim to incl...

We study a maximization problem for geometric network design. Given a set of n compact neighborhoods in R, select a point in each neighborhood, so that the longest spanning tree on these points (as vertices) has maximum length. Here we give an approximation algorithm with ratio 0.511, which represents the first, albeit small, improvement beyond 1/2. While we suspect that the problem is NP-hard ...

(V1A-TGInd), left ventricular dysfunction and dilatation were also seen, albeit at a later time point. Because the V1A receptor mediates cell signaling through G q protein, we blocked G q signaling by crossing tetracycline-transactivating factor/V1A mice with transgenic mice that expressed a small inhibitory peptide against G q. G q blockade abrogated the development of the heart failure phenot...

Liposomal encapsulated cytarabine (DepoCyte, Mundipharma GmbH, Limburg/Lahn, Germany) is a slow-release formulation of conventional cytarabine. It is licensed for intrathecal use in patients with lymphomatous and leukemic meningitis. DepoCyte obtained superior response rates, improved patient quality of life and improved the time to neurological progression in a randomized albeit small clinical...

The method for the computation of the conditional probability density function for the nonlinear Schrödinger equation with additive noise is developed. We present in a constructive form the conditional probability density function in the limit of small noise and analytically derive it in a weakly nonlinear case. The general theory results are illustrated using fiber-optic communications as a pa...

background: the technique most frequently employed for breast reconstruction, either immediate (ibr) or delayed (dbr), is the insertion of a prosthesis. the placement of a foreign body always carries the risk, albeit small, of peri-prosthetic infection and exposure of the implant that necessitates its removal, signaling the temporary or permanent failure of the reconstruction. methods: we retro...

In July 2021, the CJEU handed down its judgment in two cases regarding wearing of Islamic headscarves at work, which allows employers to ban religious and other symbols, but only under certain conditions. This article examines detail argues that it shows some improvements on previous judgments this issue present a small glimmer hope might be moving – albeit very tentatively towards more protect...