نتایج جستجو برای: akap4
تعداد نتایج: 46 فیلتر نتایج به سال:
The characteristic neuropathological changes associated with Alzheimer's disease (AD) and other lines of evidence support the amyloid cascade hypothesis. Viewing amyloid deposits as the prime instigator of dementia has now led to clinical trials of multiple strategies to remove or prevent their formation. We performed neuropathological and biochemical assessments of 3 subjects treated with bapi...
Background: Bioethanol production from lignocellulosic biomass, in particular xylose, is currently of great concern, given the abundance of this sugar in the world, because Saccharomyces cerevisiae, which is widely used for bioethanol production, is unable to naturally ferment xylose. The aim of this study was to obtain a novel yeast capable of stably producing ethanol from biomass containing x...
A human sperm-oocyte binding protein, SOB1, was purified by two dimensional gel electrophoresis and sequenced. This protein was selected because it was recognized by a monoclonal antibody that inhibited the binding of human sperm to zona-free hamster oocytes. The sequences of the tryptic peptides were used to design degenerate primers. These were used to amplify a specific fragment from human t...
Transgenic (Tg) mouse models of Alzheimer's disease (AD) have been extensively used to study the pathophysiology of this dementia and to test the efficacy of drugs to treat AD. The 5XFAD Tg mouse, which contains two presenilin-1 and three amyloid precursor protein (APP) mutations, was designed to rapidly recapitulate a portion of the pathologic alterations present in human AD. APP and its prote...
I t was shown by Crabtree in 19~9 (8) that addition of glucose to tumor slices led to a decrease in their respiratory activity, and this fact has been confirmed (6, 10). The inhibitory effect of glucose on the respiratory activity of ascites cells is much greater and may approach 40 per cent (for reviews of the "Crabtree" or "reversed Pasteur" effect in ascites tumor cells, the recent papers by...
Abstract Study question Does cryopreservation impact on transcriptome of conventional frozen human spermatozoa? Summary answer The sperm alters pathways important for fertility, although the upregulation some genes can compensate harmful effects freezing. What is known already Sperm a widely used procedure storing gametes later use, preserving fertility in patients before gonadotoxic treatments...
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