In the field of software architecture, there has been a paradigm shift from describing structural information, such as components and connectors, to documenting Architectural Knowledge (AK), such as design decisions and rationale. To this end, a series of industrial and academic domain models have been proposed for defining the concepts and their relationships in the field of AK. To a large ext...

BACKGROUND/OBJECTIVE Although Angelica keiskei (AK) has widely been utilized for the purpose of general health improvement among Asian, its functionality and mechanism of action. The aim of this study was to determine the protective effect of ethanol extract of AK (AK-Ex) on acute hepatotoxicity induced by acetaminophen (AAP) in HepG2 human hepatocellular liver carcinoma cells and HepaRG human ...

1 Geophysical Institute, University of Alaska, Fairbanks, AK, USA 2 ABR, Inc., Fairbanks, AK, USA 3 Department of Botany, University of Florida, Gainesville, FL, USA 4 Department of Civil and Environmental Engineering, University of Alaska, Fairbanks, AK, USA 5 Institute of Northern Engineering, University of Alaska, Fairbanks, AK, USA 6 Department of Geology, Moscow State University, Moscow, R...

Let un sup(ak )∞ k n and vn sup(bk ) ∞ k n be suprema. Then the following obvious relation ak ≤ un and bk ≤ vn , ∀k ≥ n ⇒ ak + bk ≤ un + vn , ∀k ≥ n shows that, upon taking the supremum over all k with k ≥ n, we get sup(ak + bk )∞ k n ≤ un + vn . This shows that for any n ≥ m, we get lim sup k→∞ (ak + bk ) inf j: j≥m sup(ak + bk )∞ k j ≤ sup(ak + bk ) ∞ k n ≤ un + vn Since we know that (un )∞ n...

Given a sequence (ak) = a0, a1, a2, . . . of real numbers, define a new sequence L(ak) = (bk) where bk = ak − ak−1ak+1. So (ak) is log-concave if and only if (bk) is a nonnegative sequence. Call (ak) infinitely log-concave if L(ak) is nonnegative for all i ≥ 1. Boros and Moll [3] conjectured that the rows of Pascal’s triangle are infinitely log-concave. Using a computer and a stronger version o...

Memory impairment is the most common symptom in patients with Alzheimer's disease (AD). Angelica keiskei (AK) has traditionally been used as a diuretic, laxative, analeptic and galactagogue. However, the anti-amnesic effects of AK and its molecular mechanisms have yet to be clearly elucidated. The aim of the present study is to evaluate the effects of AK on scopolamine-induced memory impairment...

In this report we describe cloning and expression of rat adenosine kinase (AK) in Esccherichaia coli cells as a fusion protein with 6xHis. The recombinant protein was purified and polyclonal antibodies to AK were generated in rabbits. Immunoblot analysis of extracts obtained from various rat tissues revealed two protein bands reactive with anti-AK IgG. The apparent molecular mass of these bands...

Cytokine-secreting, major histocompatibility complex-unrestricted activated killer (AK) cells are toxic to a wide range of virus-infected or malignant target cells and may be generated endogenously, eg, after bone marrow transplantation, or by infusion of cytokines such as recombinant interleukin-2 (rIL-2). Although AK cells secrete cytokines such as gamma-interferon and tumor necrosis factor, ...