1. Pseudomonas sp. N.C.I.B. 8858 grew well on Dand L-1-aminopropan-2-ol and on aminoacetone. 2. Cell-free extracts possessed high activities of inducibly formed L1-aminopropan-2-ol-NAD+ oxidoreductase, amino alcohol-ATP phosphotransferase, DL-1-aminopropan-2-ol 0-phosphate phospho-lyase and aldehyde-NAD+ oxidoreductase, but no 1-aminopropan-2-ol racemase or D-I-aminopropan-2-ol-NAD+ oxidoreduct...

The article presents the results of collaborative study method for gas chromatographic determination alcoholic fermentation volatile by-products (acetaldehyde, methanol, methyl acetate, ethyl propan-2-ol, propan-1-ol, 2-methylpropan-1-ol, butan-1-ol, and 3-methylbutan-1-ol) in beverages with volume ethanol content a range 9.9–96.0% (wine, sake, liquor, tequila, vodka, grappa, bourbon, scotch, c...

“Salting out effect” means that the addition of an organic solvent to an aqueous solution of a salt will reduce the solubility of salts and thus induce its precipitation.1 Therefore, the investigations of the physicochemical properties of inorganic salts in organic solvents – water, such as solubility data together with density, refractive index and so on, are of great scientific importance. Va...

Learning of patterns by neural networks obeying general rules of sensory transductl and of converting membrane potentials to spiking frequencies is considered. A finite number of cells Ol can sample a pattern playing on any finite number of cells without causing irrevocable sampling bias if Ol = f:H or Ol () f:H = 1". Total eneJ transfer from inputs of Ol to outputs of f:H depends on the entrop...

Objective To investigate paediatricians’ perception and awareness of off-label (OL) and unlicensed drug usage in clinical practice. Methods We conducted a questionnaire-based, observational study involving 28 departments/speciality units of four tertiary paediatrics Italian hospitals. The questionnaire was sent to a designated paediatrician in each department/speciality unit with the request th...

OL-protocadherin (OL-pc) is a transmembrane protein belonging to the cadherin superfamily, which has been shown to accumulate at cell-cell contacts via its homophilic interaction, but its molecular roles remain elusive. In this study, we show that OL-pc bound Nck-associated protein 1 (Nap1), a protein that regulates WAVE-mediated actin assembly. In astrocytoma U251 cells not expressing OL-pc, N...

We cloned a novel protocadherin cDNA, which we named OL-protocadherin (OL-pc), from mouse brain cDNA libraries. Its cytoplasmic region showed no similarities to other protocadherins, indicating that it belongs to a novel subfamily of protocadherins. Experiments using transfectants showed that OL-pc is a homophilic cell-cell adhesion molecule. The molecular mass of OL-pc was 140 kDa in the brain...

Oligodendrocyte (OL) development relies on many extracellular cues, most of which are secreted cytokines from neighboring neural cells. Although it is generally accepted that both astrocytes and microglia are beneficial for OL development, there is a lack of understanding regarding whether astrocytes and microglia play similar or distinct roles. The current study examined the effects of astrocy...

A significant and increasing number of chronic kidney disease (CKD) patients are treated with online hemodiafiltration (OL-HDF), even in the absence of more conclusive survival data. OL-HDF affords several clinical benefits including control of anemia of CKD, a common affliction in dialysis patients. In efforts to understand the underlying mechanisms that contribute to the purported benefits of...

To better understand the molecular mechanisms governing oligodendrocyte (OL) differentiation, we have used gene profiling to quantitatively analyze gene expression in synchronously differentiating OLs generated from pure oligodendrocyte precursor cells in vitro. By comparing gene expression in these OLs to OLs generated in vivo, we discovered that the program of OL differentiation can progress ...