نتایج جستجو برای: agrp عضله

تعداد نتایج: 3660  

Journal: :The Journal of clinical endocrinology and metabolism 2000
E Mihály C Fekete J B Tatro Z Liposits E G Stopa R M Lechan

We recently demonstrated that three arcuate nucleus-derived peptides, neuropeptide Y (NPY), agouti-related protein (AGRP), and alphaMSH, are contained in axon terminals that heavily innervate hypophysiotropic TRH neurons in the rat brain and may contribute to the altered set-point of the hypothalamo-pituitary-thyroid axis during fasting. To determine whether a similar regulatory system exists i...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2012
Clemence Blouet Shun-Mei Liu Young-Hwan Jo Streamson Chua Gary J Schwartz

Thioredoxin interacting protein (TXNIP) has recently been described as a key regulator of energy metabolism through pleiotropic actions that include nutrient sensing in the mediobasal hypothalamus (MBH). However, the role of TXNIP in neurochemically specific hypothalamic subpopulations and the circuits downstream from MBH TXNIP engaged to regulate energy homeostasis remain unexplored. To evalua...

2012
Lei Jiang Zheng Miao Richard H. Kimura Adam P. Silverman Gang Ren Hongguang Liu Hankui Lu Jennifer R. Cochran Zhen Cheng

Agouti-related protein (AgRP) is a 4-kDa cystine-knot peptide of human origin with four disulfide bonds and four solvent-exposed loops. The cell adhesion receptor integrin α(v)β(3) is an important tumor angiogenesis factor that determines the invasiveness and metastatic ability of many malignant tumors. AgRP mutants have been engineered to bind to integrin α(v)β(3) with high affinity and specif...

2013
Roxanne Dutia Andrea J. Kim Matthew Modes Robert Rothlein Jane M. Shen Ye Edward Tian Jumana Ihbais Sam F. Victory Carmen Valcarce Sharon L. Wardlaw

Activation of brain melanocortin-4 receptors (MC4-R) by α-melanocyte-stimulating hormone (MSH) or inhibition by agouti-related protein (AgRP) regulates food intake and energy expenditure and can modulate neuroendocrine responses to changes in energy balance. To examine the effects of AgRP inhibition on energy balance, a small molecule, non-peptide compound, TTP2515, developed by TransTech Pharm...

Journal: :American journal of physiology. Regulatory, integrative and comparative physiology 2002
Huiyuan Zheng Michele M Corkern Scott M Crousillac Laurel M Patterson Curtis B Phifer Hans-Rudolf Berthoud

Agouti-related protein (AgRP) is coexpressed with neuropeptide Y (NPY) in a population of neurons in the arcuate nucleus (ARC) of the hypothalamus and stimulates food intake for up to 7 days if injected intracerebroventricularly. The prolonged food intake stimulation does not seem to depend on continued competition at the melanocortin-4 receptor (MC4R), because the relatively specific MC4R agon...

2011
Olha Ilnytska Adrian M. Stütz MieJung Park-York David A. York David M. Ribnicky Aamir Zuberi William T. Cefalu George Argyropoulos

OBJECTIVE The agouti-related protein (Agrp) is a powerful orexigenic peptide, but little is known about its transcriptional regulation. The objective of this study was to determine molecular mechanisms for the activation of hypothalamic Agrp and identify compounds that stimulate appetite. RESEARCH DESIGN AND METHODS We used promoter analyses methods, hypothalamic cell culture and transfection...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2009
Louise E Olofsson Andrew A Pierce Allison W Xu

In female mammals including rodents and humans, feeding decreases during the periovulatory period of the ovarian cycle, which coincides with a surge in circulating estrogen levels. Ovariectomy increases food intake, which can be normalized by estrogen treatment at a dose and frequency mimicking those during the estrous cycle. Furthermore, administration of estrogen to rodents potently inhibits ...

امیر رشید لمیر شادمهر میردار عباس قنبری نیاکی محمد قاسمی مسلم حجتی

چکیده مقدّمه: پروتئین وابسته به آگوتی (AgRP) یک پپتید اشتهاآور است که از هیپوتالاموس و بافت‌‌های دیگر ترشّح می‌شود. این پپتید تأثیر قوی بر رفتار دریافت غذا و هموستاز انرژی دارد. گزارش شده است که در شرایط منفی تعادل انرژی ممکن است لنفوسیت، AgRP را ترشّح کند و با بازسازی انرژی سلولی متوقّف ‌شود. هدف از پژوهش حاضر بررسی اثر قند خوراکی بر AgRP لنفوسیت خون محیطی و غلظت گلوکز پلاسما پس از یک جلسه فعّالیّت ...

Objective: Melanocortin-4 receptor (MC4R) and agouti-related peptide (AgRP) are involved in energy homeostasis in the rat. The aim of the present study was to evaluate the expression of MC4R and AgRP mRNAs in arcuate nucleus (ARC) during long term malnutrition of female ovariectomized rats. Materials and Methods: Ten female ovariectomized rats were divided into two equal groups (n=6) of normal ...

2011
Marcus P. Corander Debra Rimmington Benjamin G. Challis Stephen O'Rahilly Anthony P. Coll

The hypothalamic melanocortin system is unique among neuropeptide systems controlling energy homeostasis, in that both anorexigenic proopiomelanocortin (POMC)-derived and orexigenic Agouti related-peptide (AgRP)-derived ligands act at the same receptors, namely melanocortin 3 and 4 receptors (MC3/4R). AgRP clearly acts as a competitive antagonist at MC3R and MC4R but may also have an inverse ag...

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