نتایج جستجو برای: agrp
تعداد نتایج: 820 فیلتر نتایج به سال:
Neurochemical phenotype of hypothalamic neurons showing Fos expression 23 h after intracranial AgRP.
Agouti-related protein (AgRP) is coexpressed with neuropeptide Y (NPY) in a population of neurons in the arcuate nucleus (ARC) of the hypothalamus and stimulates food intake for up to 7 days if injected intracerebroventricularly. The prolonged food intake stimulation does not seem to depend on continued competition at the melanocortin-4 receptor (MC4R), because the relatively specific MC4R agon...
OBJECTIVE The agouti-related protein (Agrp) is a powerful orexigenic peptide, but little is known about its transcriptional regulation. The objective of this study was to determine molecular mechanisms for the activation of hypothalamic Agrp and identify compounds that stimulate appetite. RESEARCH DESIGN AND METHODS We used promoter analyses methods, hypothalamic cell culture and transfection...
Functional requirement of AgRP and NPY neurons in ovarian cycle-dependent regulation of food intake.
In female mammals including rodents and humans, feeding decreases during the periovulatory period of the ovarian cycle, which coincides with a surge in circulating estrogen levels. Ovariectomy increases food intake, which can be normalized by estrogen treatment at a dose and frequency mimicking those during the estrous cycle. Furthermore, administration of estrogen to rodents potently inhibits ...
چکیده مقدّمه: پروتئین وابسته به آگوتی (AgRP) یک پپتید اشتهاآور است که از هیپوتالاموس و بافتهای دیگر ترشّح میشود. این پپتید تأثیر قوی بر رفتار دریافت غذا و هموستاز انرژی دارد. گزارش شده است که در شرایط منفی تعادل انرژی ممکن است لنفوسیت، AgRP را ترشّح کند و با بازسازی انرژی سلولی متوقّف شود. هدف از پژوهش حاضر بررسی اثر قند خوراکی بر AgRP لنفوسیت خون محیطی و غلظت گلوکز پلاسما پس از یک جلسه فعّالیّت ...
Objective: Melanocortin-4 receptor (MC4R) and agouti-related peptide (AgRP) are involved in energy homeostasis in the rat. The aim of the present study was to evaluate the expression of MC4R and AgRP mRNAs in arcuate nucleus (ARC) during long term malnutrition of female ovariectomized rats. Materials and Methods: Ten female ovariectomized rats were divided into two equal groups (n=6) of normal ...
Loss of Agouti-Related Peptide Does Not Significantly Impact the Phenotype of Murine POMC Deficiency
The hypothalamic melanocortin system is unique among neuropeptide systems controlling energy homeostasis, in that both anorexigenic proopiomelanocortin (POMC)-derived and orexigenic Agouti related-peptide (AgRP)-derived ligands act at the same receptors, namely melanocortin 3 and 4 receptors (MC3/4R). AgRP clearly acts as a competitive antagonist at MC3R and MC4R but may also have an inverse ag...
Hypothalamic neurons expressing Agouti-related peptide (AgRP) are critical for initiating food intake, but druggable biochemical pathways that control this response remain elusive. Thus, genetic ablation of insulin or leptin signaling in AgRP neurons is predicted to reduce satiety but fails to do so. FoxO1 is a shared mediator of both pathways, and its inhibition is required to induce satiety. ...
مقدمه: agrp یا پروتئین وابسته به آگوتی یک نروپپتاید اشتها آور است که موثر در رفتار دریافت غذا، انتخاب غذا، تنظیم وزن، هموستاز انرژی و چاقی می باشد و سطح آن هنگام روزه داری، هیپوگلیسیمی(کم قندی) و چاقی بالا می رود. هدف از تحقیق حاضر مقایسه اثر یک جلسه تمرین مقاومتی دایره ای و تمرین هوازی بر بیان ژن agrp لنفوسیت زنان جوان تمرین کرده می باشد. روش تحقیق: 24 زن تمرین کرده به طور داوطلبانه انتخاب و...
Agouti-related protein encodes a neuropeptide that stimulates food intake. Agrp expression in the brain is restricted to neurons in the arcuate nucleus of the hypothalamus and is elevated by states of negative energy balance. The molecular mechanisms underlying Agrp regulation, however, remain poorly defined. Using a combination of transgenic and comparative sequence analysis, we have previousl...
Agouti-related protein (Agrp) encodes a hypothalamic neuropeptide that promotes positive energy balance by stimulating food intake and reducing energy expenditure. Agrp expression in the brain is restricted to neurons within the arcuate nucleus of the hypothalamus, and expression levels are elevated as a consequence of food deprivation. We tested a series of bacterial artificial chromosome repo...
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