A life-threatening manifestation of Covid-19 infection is a cytokine storm that requires hospitalization and supplemental oxygen. Various strategies to reduce inflammatory cytokines have had some success in limiting improving survival. Agonists adenosine A2A receptors (A2AR) release from most immune cells. Apadenoson potent selective anti-inflammatory analog reduces inflammation. When administe...

TNFR2 agonists have been investigated as potential therapies for inflammatory diseases due to their ability activate and expand immunosuppressive CD4+Foxp3+ Treg cells myeloid-derived suppressor (MDSCs). Despite being predominantly expressed in at high levels, activated effector T also exhibit a certain degree of expression. Consequently, the role signaling coordinating immune or responses unde...

background: hormone therapy is currently the mainstay in the management of locally advanced and metastatic prostate cancer. we performed a systematic review to compare safety, efficacy and effectiveness of degarelix, a new gonadotropin-releasing hormone (gnrh) antagonist (blocker), versus gonadotropin-releasing hormone (gnrh) agonists. methods: medline, web of science and the cochrane library w...

Background Post cardiac surgery acute kidney injury (AKI) secondary to postoperative low output syndrome (LCOS), is a serious complication. Positive inotropic agents are the main line of treatment for LCOS with different degrees improvement function & nephroprotective efficacy Levosimendan calcium sensitizer in muscles, which has comparable positive and effects that classic beta2 agonists.Objec...

  It has been revealed that dopamine (DA) modulates gastro-duodenal responses to stress. Several investigations have been made to identify the mechanisms and/or receptors by which DA or its promoters exert their gastroprotective function against stress, however there are many discrepancies in this respect. In order to clarify the relative contribution and/or interaction of two DA receptor subty...

The effects of exogenous abscisic acid (ABA) and its two agonists, Sulfacetamide (Sa) and Sulfasalazine (SS) on tolerance of tomato (Lycopersicon esculentum Mill. Cv. Super chief) under drought stress were studied. Eight-week plants were treated with ABA (25 and 50 mg/L), Sulfacetamide (Sa) (25, 50 and 100 mg/L) and Sulfasalazine (SS) (25, 50 and 100 mg/L). Solutions were sprayed daily and samp...