The organization of the brain serotonergic system appears to have been highly conserved across the vertebrate subphylum. In fish as well as in other vertebrates, brain serotonin (5-HT), mainly acts as a neuromodulator with complex effects on multiple functions. It is becoming increasingly clear that acute and chronic increase in brain 5-HT neurotransmission have very different effects. An acute...

Loss of appetite in the medically ill and ageing populations is a major health problem and a significant symptom in cachexia syndromes, which is the loss of muscle and fat mass. Ghrelin is a gut-derived hormone which can stimulate appetite. Herein we describe a novel, simple, non-peptidic, 2-pyridone which acts as a selective agonist for the ghrelin receptor (GHS-R1a). The small 2-pyridone demo...

‎‎The investigation of equational compactness was initiated by‎ ‎Banaschewski and Nelson‎. ‎They proved that pure injectivity is‎ ‎equivalent to equational compactness‎. ‎Here we define the so‎ ‎called sequentially compact acts over semigroups and study‎ ‎some of their categorical and homological properties‎. ‎Some‎ ‎Baer conditions for injectivity of S-acts are also presented‎.

While institutional theory has focused on the effect of institutions on individual organizations, this paper addresses the relationships between institutions. Using a case history approach, it examines the relationship of one institution, the University, within an institutional complex. The study suggests that the University acts and has a role akin to the Fool in the medieval royal court. The ...

Cimetidine is the prototype antiulcer drug having the imidazole nucleus and acts by blocking histamine H2 receptors. Keeping this context in mind, an attempt has been made to study the antihistaminic activity of some novel 1-substituted imidazole derivatives on isolated guinea pig atria to reveal their desired pharmacological effects. In the present revision, some 1-substituted Imidazoles (1a-1...

The 26,23-lactone derivative of 1alpha,25-dihydroxyvitamin D3, TEI-9647, is a partial antagonist of the of human vitamin D receptor (VDR). However, we found that TEI-9647 in rat cells behaves as a weak VDR agonist. This behavior could be mimicked in human cells by the double mutagenesis of human VDR (specifically C403S and C410N). The increased agonistic action of TEI-9647 correlates to a gain ...

An agonistic display by a white shark was observed and photographed during cage dive at Guadalupe Island in November 2015. Exhibiting exaggerated pectoral fin depression, behaviors have been previously described several species. This account may be the first record of close proximity to caged diver, exhibiting strong depression significantly dipped, mid-agonistic display. Such displays should c...

Fas triggering by agonistic antibodies or by its cognate ligand, FasL, induces apoptotic cell death, whereas mutation in the Fas death domain is associated with lymphoma progression. On prolonged culture in the presence of an agonistic anti-Fas antibody, we raised a Jurkat cell line resistant to agonistic antibodies but still sensitive to soluble FasL, which carried at the heterozygous state, a...

The paper deals with the possibilities of engaged interdisciplinary activity implemented at crossroads librarianship and contemporary art practices. By relying on theoretical concepts which critical is based one hand, other a possibility shown their interference aim to introduce perspective within through establish new methodology two disciplines. aforementioned demonstrated in coexistence S. K...